Tracer library / [68Ga]PEG2-COU

[68Ga]PEG2-COU

Also written as [Ga-68]Ga-PEG2-COU
Radionuclide
Ga-68 t½ 67.71 min
Modality
PET
Production route
—
Stage
Reported once
Syntheses indexed
1

What it is

Compound class
FAP-targeted small-molecule radiotracer with albumin-binding coumarin moiety (FAPI-based)
Target / mechanism
Fibroblast activation protein (FAP) PMID 42569132
Clinical application
Imaging of FAP-overexpressing tumors (stromal fibroblast activation protein in various tumors) PMID 42569132
Theranostic pair
—

Published syntheses

ModuleCassettePurificationYield %RCP %Precursor / supplierSource
——SPE91.5%98.5%PEG2-COU42569132
2026 ACS Omega

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Notes

Added at stage 22: promoted from 'Reported once' (single-article, no diagnostic pair at discovery) because a full-text synthesis with extracted data exists in parsed-therapy.xlsx -- PMID(s): 42569132. Target/mechanism, clinical application, indications, approval and precursor fields still need per-agent research and are intentionally left empty. Compound class inferred from precursor name (not stated outright) -- PMID 42569132: 'Compound PEG2-COU (m = 2): obtained as a faint yellow solid in 20.3% yield.'. | Stage 30 (2026-09-18): Modality was 'Therapy' -- a bucket value given to every agent found by the therapy-oriented bulk search (stages 21-22), not a source statement. Corrected to PET: Ga-68 is a positron emitter used only for PET imaging. Linked articles: PMID 42569132.
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