Tracers / [18F]FBAM

[18F]FBAM

Also written as [18F]FBAM; [F-18]FBAM
Radionuclide
F-18 t½ 109.77 min
Modality
PET
Production route
—
Stage
preclinical
Syntheses indexed
1
Radiochemistry methodologyPreclinical only, no clinical indication yetApoptosis and early treatment response

What it is

Compound class
Thiol-reactive prosthetic group / bifunctional 18F-labeling agent (N-[6-(4-[18F]fluorobenzylidene)aminooxyhexyl]maleimide)
Target / mechanism
Phosphatidylserine (PS) PMID 26205076
Clinical application
Apoptosis imaging in murine tumor model of apoptosis (camptothecin-induced apoptosis in Jurkat cells and EL4 tumor model) PMID 26205076
Theranostic pair
—

Regulatory status

FDA
—
EMA (centralised)
—
Other approvals
—
Brand names
—

Clinical use

Typical injected activity
—
Uptake time
—

Reported in the literature. Not a dosing recommendation.

Published syntheses

ModuleCassettePurificationYield %RCP %Precursor / supplierSource
——SPE29±4%
yes
94-98%—21507666
2011 Appl Radiat Isot
was adapted to a remotely controlled synthesizer module — the final [(18)F]FBAM was obtained in a decay-corrected radiochemical yield of 29±4% (related to [(18)F]fluoride, n=12)

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Quality control Preliminary — inferred from compound class

Ph. Eur. monograph
—
USP monograph
—
AppearancepHRCP HPLCRCP TLCHPLC UVRadionuclidic (HPGe)Half-lifeActivityEndotoxins (LAL)SterilityFilter integrity
How this set was arrived at. base set per Ph. Eur. general monograph 0125 (rule); organic-phase radiosynthesis assumed from isotope/compound class, no synthesis data confirming it -> GC residual solvents (preliminary); conventional nucleophilic 18F-fluorination assumed from isotope/compound class, no synthesis data confirming K222 use -> Kryptofix test (preliminary)

Tests listed by reference only. Monograph texts are copyrighted and are not reproduced here. How these are derived

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Notes

Added from reverse module search (stage 6); 1 article(s) with F-18.