Tracer library / [68Ga]Ga-BPAMD
[68Ga]Ga-BPAMD
Also written as [68Ga]Ga-BPAMD; [Ga-68]Ga-BPAMD; BPAMD; Ga-68 BPAMD
- Radionuclide
- Ga-68 t½ 67.71 min
- Modality
- PET
- Production route
- —
- Stage
- Clinical research
- Syntheses indexed
- 5
What it is
- Compound class
- DOTA-conjugated bisphosphonate
- Target / mechanism
- Bisphosphonate binding to bone mineral (hydroxyapatite) PMID 39568296
- Clinical application
- PET imaging of bone metastases PMID 39568296
- Theranostic pair
- [161Tb]Tb-BPAMD
Published syntheses
| Module | Cassette | Purification | Yield % | RCP % | Precursor / supplier | Source |
|---|---|---|---|---|---|---|
| — Elysia-Raytest | vendor cassette | none | >91% | >93% | BPAMD ABX | 39568296 2024 J Labelled Comp Radiopharm GAIA® V2/LUNA® synthesis module (Elysia‐Raytest, Germany) - [68Ga]Ga‐BPAMD was obtained with > 93% RCP and > 91% RCY, in less than 25 min. |
| — Elysia-Raytest | vendor cassette | none | >91% | >93% | BPAMD ABX | 39568296 2024 J Labelled Comp Radiopharm GAIA® V2/LUNA® synthesis module (Elysia‐Raytest, Germany) - [68Ga]Ga‐BPAMD was obtained with > 93% RCP and > 91% RCY, in less than 25 min. |
| — Elysia-Raytest | vendor cassette | none | >91% | >93% | BPAMD ABX | 39568296 2024 J Labelled Comp Radiopharm GAIA® V2/LUNA® synthesis module (Elysia‐Raytest, Germany) - [68Ga]Ga‐BPAMD was produced in good radiochemical purity (> 93%) and high radiochemical yield (> 91%) using 0.3 M HEPES buffer. |
| — Elysia-Raytest | vendor cassette | none | >91% | >93% | BPAMD ABX | 39568296 2024 J Labelled Comp Radiopharm The second sequence was based on the combined GAIA®/LUNA® modules (configuration B, Figure 2C,D), lasted 23.5 min and allowed the use of different reaction vial models. - [68Ga]Ga‐BPAMD was produced in good radiochemical purity (> 93%) and high radiochemical yield (> 91%) using 0.3 M HEPES buffer. |
| Manual synthesis n/a | — | — | — | >95% | — | 27907840 2017 Nucl Med Biol without use of any synthesis module |
Precursor
- Common precursor
- —
- Suppliers seen in the literature
- —
- Cited suppliers in indexed syntheses
- ABX
- Typical final purification
- —
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Get in touchQuality control Preliminary - inferred from compound class
- Ph. Eur. monograph
- not verified No Ph. Eur. check is recorded for this entry.
- USP monograph
- not verified No USP check is recorded for this entry.
How this set was arrived at. base set per Ph. Eur. general monograph 0125 (rule); radiometal tracer -> metal impurities (rule); Ga-68, generator production assumed (no synthesis data found) -> Ge-68 breakthrough (preliminary)
Tests listed by reference only. Monograph texts are copyrighted and are not reproduced here. How these are derived
Setting up quality control?We can help you scope the equipment needed to release [68Ga]Ga-BPAMD.
Get in touchNotes
Added from reverse module search (stage 6); 2 article(s) with Ga-68. Also seen with Lu-177[1] (too few articles for own row). Stage set/updated at stage 39 from PMID 27907840: 'The clinical utility of the synthesized radiopharmaceuticals was ascertained by performing PET scans in human patients.'.