Tracers / [18F]F-PSMA-617-NODA

[18F]F-PSMA-617-NODA

Also written as [18F]F-PSMA-617-NODA; [F-18]F-PSMA-617-NODA
Radionuclide
F-18 t½ 109.77 min
Modality
PET
Production route
—
Stage
—
Syntheses indexed
2
Glioma and brain tumoursProstate cancerPreclinical only, no clinical indication yet

What it is

Compound class
PSMA-617-NODA derivative (PSMA-targeting urea-based small molecule with NODA chelator, radiolabelled via [18F]AlF2+)
Target / mechanism
PSMA (prostate-specific membrane antigen) targeting ligand PMID 38904859
Clinical application
Imaging (and therapy) of prostate cancer PMID 38904859
Theranostic pair
—

Regulatory status

FDA
—
EMA (centralised)
—
Other approvals
—
Brand names
—

Clinical use

Typical injected activity
—
Uptake time
—

Reported in the literature. Not a dosing recommendation.

Published syntheses

ModuleCassettePurificationYield %RCP %Precursor / supplierSource
AllinOne (AiO)
Trasis
custom manifoldHPLC23 ± 3.3%
no
>99%PSMA-617-NODA precursor (compound 7)
In-house / non-commercial (various)
38904859
2024 EJNMMI Radiopharm Chem
radiosynthesis system Trasis All-in-One — a RCY of 23 ± 3.3% (n = 4), not decay corrected
AllinOne (AiO)
Trasis
custom manifoldHPLC23 ± 3.3%
no
>99%PSMA-617-NODA precursor (compound 7)
In-house / non-commercial (various)
38904859
2024 EJNMMI Radiopharm Chem
radiosynthesis system Trasis All-in-One (Additional file 1: S73) — a RCY of 23 ± 3.3% (n = 4), not decay corrected

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Quality control Preliminary — inferred from compound class

Ph. Eur. monograph
—
USP monograph
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AppearancepHRCP HPLCRCP TLCHPLC UVRadionuclidic (HPGe)Half-lifeActivityEndotoxins (LAL)SterilityFilter integrityMolar activity
How this set was arrived at. base set per Ph. Eur. general monograph 0125 (rule); receptor ligand with a saturable target -> molar activity (rule); organic-phase radiosynthesis assumed from isotope/compound class, no synthesis data confirming it -> GC residual solvents (preliminary); conventional nucleophilic 18F-fluorination assumed from isotope/compound class, no synthesis data confirming K222 use -> Kryptofix test (preliminary)

Tests listed by reference only. Monograph texts are copyrighted and are not reproduced here. How these are derived

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Notes

Added from reverse module search (stage 6); 3 article(s) with F-18. Compound class inferred from precursor name (not stated outright) -- PMID 38904859: 'precursors 7 (PSMA-617-NODA precursor)'.