Tracer library / [68Ga]SB04028

Structure of SB04028 (unlabelled parent compound, from PubChem) — Unlabelled parent compoundPubChem CID 166034864

[68Ga]SB04028

Also written as [Ga-68]Ga-SB04028

Radionuclide: Ga-68 t½ 67.71 min
Modality: PET
Production route: —
Stage: Preclinical
Syntheses indexed: 1

Preclinical only, no clinical indication yet

What it is

Compound class: DOTA-conjugated (R)-pyrrolidin-2-yl-boronic acid-based FAP-targeted small molecule ligand
Target / mechanism: Fibroblast activation protein (FAP) inhibitor PMID 37375746
Clinical application: Imaging of carcinomas with FAP-overexpressing reactive stromal fibroblasts PMID 37375746
Theranostic pair: —

Published syntheses

Module	Cassette	Purification	Yield %	RCP %	Precursor / supplier	Source
—	—	HPLC	19-58% decay-corrected	>92%	SB04028	37375746 2023 Pharmaceuticals (Basel)

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Notes

Added at stage 22: promoted from 'Reported once' (single-article, no diagnostic pair at discovery) because a full-text synthesis with extracted data exists in parsed-therapy.xlsx -- PMID(s): 37375746. Target/mechanism, clinical application, indications, approval and precursor fields still need per-agent research and are intentionally left empty. Stage set/updated at stage 23 from PMID 37375746: 'Synthesis and Preclinical Evaluation of Novel 68Ga-Labeled (R)-Pyrrolidin-2-yl-boronic Acid-Based PET Tracers for Fibroblast Activation Protein-Targeted Cancer Imaging.'. | Stage 30 (2026-09-18): Modality was 'Therapy' -- a bucket value given to every agent found by the therapy-oriented bulk search (stages 21-22), not a source statement. Corrected to PET: Ga-68 is a positron emitter used only for PET imaging. Linked articles: PMID 37375746.