Tracers / [18F]FRPG

[18F]FRPG

Also written as (R)-4-(3-[18F]fluoropropyl)-L-glutamic acid; [18F]FRPG; [F-18]FRPG
Radionuclide
F-18 t½ 109.7 min
Modality
PET
Production route
Cyclotron liquid target
Stage
Research
Syntheses indexed
0
Redox and oxidative stressPreclinical only, no clinical indication yet

What it is

Compound class
Amino acid
Target / mechanism
(R)-stereoisomer of FSPG; evaluated for recognition by the cystine/glutamate antiporter (system xc-) PMID 35198080 / DOI 10.7150/thno.63237
Clinical application
(preclinical) (R)-enantiomer of FSPG; used as a stereochemical comparator in system xc- transporter imaging studies PMID 35198080 / DOI 10.7150/thno.63237
Theranostic pair
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Regulatory status

FDA
No Drugs@FDA / openFDA drug registry — no approved application found; search: https://www.accessdata.fda.gov/scripts/cder/daf/index.cfm?event=BasicSearch.process&searchTerm=FRPG+glutamic+acid
EMA (centralised)
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Other approvals
—
Brand names
—

Clinical use

Typical injected activity
—
Uptake time
—

Reported in the literature. Not a dosing recommendation.

Published syntheses

No synthesis has been parsed for this agent yet.

Precursor

Common precursor
Corresponding naphthalenesulfonyl precursor (the (2R,4R) analogue of the FSPG precursor) PMID 35198080 / DOI 10.7150/thno.63237
Suppliers seen in the literature
Life Molecular Imaging
Typical final purification
HPLC

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Quality control Preliminary — inferred from compound class

Ph. Eur. monograph
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USP monograph
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AppearancepHRCP HPLCRCP TLCHPLC cond.Radionuclidic (HPGe)Half-lifeActivityEndotoxins (LAL)SterilityFilter integrity
How this set was arrived at. base set per Ph. Eur. general monograph 0125 (rule); organic-phase radiosynthesis assumed from isotope/compound class, no synthesis data confirming it -> GC residual solvents (preliminary); conventional nucleophilic 18F-fluorination assumed from isotope/compound class, no synthesis data confirming K222 use -> Kryptofix test (preliminary); STAGE 17.4 recheck by compound class ('Amino acid'): HPLC UV -> HPLC cond. (non-aromatic glutamate analogue, same reasoning as FSPG -- weak UV chromophore)

Tests listed by reference only. Monograph texts are copyrighted and are not reproduced here. How these are derived

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