Tracer library / [68Ga]Ga-FAPI
[68Ga]Ga-FAPI
Also written as [68Ga]Ga-FAPI; [Ga-68]Ga-FAPI; FAPI; Ga-68 FAPI
- Radionuclide
- Ga-68 t½ 67.71 min
- Modality
- PET
- Production route
- —
- Stage
- Clinical research
- Syntheses indexed
- 5
What it is
- Compound class
- FAP inhibitor (FAPI) - quinoline-based fibroblast activation protein inhibitor
- Target / mechanism
- Targets fibroblast activation protein (FAP) overexpressed on cancer-associated fibroblasts PMID 34556528
- Clinical application
- PET/CT imaging of FAP-expressing tumors and tumor stroma, used diagnostically and for theranostic pairing with therapeutic radionuclides PMID 34556528
- Theranostic pair
- [177Lu]Lu-FAPI
Published syntheses
| Module | Cassette | Purification | Yield % | RCP % | Precursor / supplier | Source |
|---|---|---|---|---|---|---|
| Manual synthesis | — | SPE | — | >95% | DOTA-2P(FAPI)2 | 39800373 2025 J Immunother Cancer approximately 25 nmol of FAPI-46 and DOTA-2P(FAPI)2 was dissolved in 1 mL of NaAc (0.25 M aqueous solution), and 4 mL of 68GaCl3 solution (1.1 GBq, dissolved in 0.05 M HCl) was added |
| Manual synthesis | — | SPE | >90% | >95% | DOTA-4P(FAPI)4 | 37321827 2023 J Nucl Med For 68Ga labeling, approximately 25.4 nmol of FAPI-46, DOTA-2P(FAPI)2, or DOTA-4P(FAPI)4 were dissolved in 1 mL of NaAc (0.25 M in water) and added to 4 mL of 68GaCl3 solution (1.3 GBq in 0.05 M HCl). - 68Ga, 64Cu, and 177Lu were labeled in more than 90% yield with radiochemical purity of more than 95%. |
| Manual synthesis | — | SPE | >90% | >95% | DOTA-2P(FAPI)2 | 37321827 2023 J Nucl Med For 68Ga labeling, approximately 25.4 nmol of FAPI-46, DOTA-2P(FAPI)2, or DOTA-4P(FAPI)4 were dissolved in 1 mL of NaAc (0.25 M in water) and added to 4 mL of 68GaCl3 solution (1.3 GBq in 0.05 M HCl). - 68Ga, 64Cu, and 177Lu were labeled in more than 90% yield with radiochemical purity of more than 95%. |
| — | — | — | — | >99% | DOTAGA.Glu2.(FAPI)2 | 42448891 2026 Eur J Nucl Med Mol Imaging |
| — | — | — | — | >99% | DOTAGA.PEG2.Glu.(FAPI)2 | 42448891 2026 Eur J Nucl Med Mol Imaging |
Clinical literature
Clinical studies in the indexed corpus, ordered by design (multicentre, prospective, retrospective, others, case reports last) and then by year. Titles and links only, as published; this is not a summary of the evidence.
- The role of 68Ga-FAPi PET/CT in Staging and Restaging of Breast Cancer Subtypes with Limited 18F-FDG Uptake.2026 · Mol Imaging Radionucl Ther · Prospective
- Spatiotemporal voxel-wise concordance between 68Ga-FAPI and 18F-FDG PET/CT: association with pathologic response in esophageal squamous cell carcinoma receiving neoadjuvant chemoradiotherapy.2026 · Eur J Nucl Med Mol Imaging · Prospective, retrospective
- Increased synovial and entheseal fibroblast activation detected by 68Ga-FAPI-PET/CT is associated with the development of psoriatic arthritis in psoriasis patients with arthralgia.2026 · RMD Open · Prospective
- Metabolic response prediction using 68Ga-FAPI PET/CT in Non-Hodgkin lymphoma treated with chemotherapy: a pilot study.2025 · Cancer Imaging · Prospective
- Comparative Analysis of Lesion Detection and Uptake Characteristics of 68Ga-FAPI PET/CT Versus 18F-FDG PET/CT in Gastric Cancer.2026 · J Gastrointest Cancer · Retrospective
- Comparison of 68Ga-FAPI and 18F-DOPA PET/CT in patients with medullary thyroid cancer.2026 · Front Endocrinol (Lausanne) · Retrospective
- The Schrödinger's Cat Paradox: Can MAMMI PET with 68Ga-FAPI Determine Pathological Complete Response to Neoadjuvant Chemotherapy in Breast Cancer Omitting Surgery?2026 · Cancer Biother Radiopharm · Retrospective
- Non-specific uptake of 68Ga-FAPI PET/CT in the pancreas and its related factor: a retrospective, single-center study.2025 · BMC Cancer · Retrospective
- Efficacy of [68Ga]Ga-FAPI-PET as a non-invasive evaluation method of liver fibrosis.2025 · Ann Nucl Med · Retrospective
- A Curious "Mickey Mouse" Sign: Physiological FAPI Uptake in Uterus Didelphys on 68 Ga-FAPI PET/CT.2026 · Clin Nucl Med · Clinical study
Show all 22 clinical studies
- Discordant 68 Ga-FAPI and 18 F-FDG Uptake in Reactive Lymph Nodes in a Case of Esophageal Cancer and Systemic Lupus Erythematosus.2026 · Clin Nucl Med · Clinical study
- Bicornuate Uterus With FAPI Uptake Mimicking Ovarian Metastasis.2026 · Clin Nucl Med · Clinical study
- Widespread Skeletal Metastases in Medullary Thyroid Carcinoma: Diagnostic Superiority of 68 Ga-FAPI PET/CT Over Somatostatin Receptor-Targeted Imaging.2026 · Clin Nucl Med · Clinical study
- Superior mucoepidermoid carcinoma detection with ⁶⁸Ga-FAPI PET/CT reflects FAP-α expression and MAML2 fusion status.2026 · Sci Rep · Clinical study
- Molecular imaging of aortic fibroblast activation protein through 68Ga-FAPI-PET/CT: Association with aortic dilation.2026 · Eur J Nucl Med Mol Imaging · Clinical study
- Not All That Glows Is Cancer: Ga-68 FAPI PET/CT Uptake in Eosinophilic Esophagitis.2026 · Clin Nucl Med · Clinical study
- 68Gallium-labelled fibroblast activation protein inhibitor uptake in joints: a single-center cohort analysis of 268 patients.2026 · Eur J Nucl Med Mol Imaging · Clinical study
- 68GA-FAPI PET/CT IN DIAGNOSIS OF THE BREAST CANCER DEPENDING ON THE MOLECULAR SUBTYPES AND EXPRESSION STATUS OF HUMAN EPIDERMAL GROWTH FACTOR RECEPTOR 2 (HER2/NEU).2025 · Georgian Med News · Clinical study
- Increased 68 Ga-FAPI Uptake of Ureteric Fibroepithelial Polyp and Costal Cyst Mimicking Malignancy With Bone Metastasis.2025 · Clin Nucl Med · Clinical study
- 68 Ga-FAPI PET/MR for Active Thyroid Eye Disease Following Thyroidectomy: A Case Supporting Its Dual Role in Clinical Management.2025 · Clin Nucl Med · Clinical study
- The Alien Antenna Sign: Physiological ⁶⁸Ga-FAPI Uptake in the Round Ligament.2026 · Clin Nucl Med · Case report
- Increased 68 Ga-FAPI Uptake of Nasal Polyp in a Patient With Lung Cancer.2026 · Clin Nucl Med · Case report
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Get in touchQuality control Preliminary - inferred from compound class
- Ph. Eur. monograph
- not verified No Ph. Eur. check is recorded for this entry.
- USP monograph
- not verified No USP check is recorded for this entry.
How this set was arrived at. base set per Ph. Eur. general monograph 0125 (rule); radiometal tracer -> metal impurities (rule); Ga-68, generator production assumed (no synthesis data found) -> Ge-68 breakthrough (preliminary); receptor ligand with a saturable target -> molar activity (rule)
Tests listed by reference only. Monograph texts are copyrighted and are not reproduced here. How these are derived
Setting up quality control?We can help you scope the equipment needed to release [68Ga]Ga-FAPI.
Get in touchNotes
Added from reverse module search (stage 6); 7 article(s) with Ga-68. Also seen with C-11[1], F-18[1] (too few articles for own row). Stage set/updated at stage 23 from PMID 34556528: 'Synthesis, Preclinical Evaluation, and a Pilot Clinical PET Imaging Study of 68Ga-Labeled FAPI Dimer.'. | Stage 28: added indication(s) onc-sarcoma from consolidated missing-rubric review. | Stage 30 (2026-09-18): Stage was 'pilot clinical study'; normalised to 'Clinical research', original wording kept here.