Tracers / [177Lu]Lu-FAPI
[177Lu]Lu-FAPI
Also written as [177Lu]Lu-FAPI; [Lu-177]Lu-FAPI; FAPI
- Radionuclide
- Lu-177 t½ 9585 min
- Modality
- Therapy
- Production route
- —
- Stage
- —
- Syntheses indexed
- 7
What it is
- Compound class
- FAP inhibitor (FAPI) multimer with DOTA chelator
- Target / mechanism
- Fibroblast activation protein (FAP) targeting PMID 37321827
- Clinical application
- —
- Theranostic pair
- <a href="/tracers/ga68-fapi/">ga68-fapi</a>
Regulatory status
- FDA
- —
- EMA (centralised)
- —
- Other approvals
- —
- Brand names
- —
Clinical use
- Typical injected activity
- —
- Uptake time
- —
Reported in the literature. Not a dosing recommendation.
Published syntheses
| Module | Cassette | Purification | Yield % | RCP % | Precursor / supplier | Source |
|---|---|---|---|---|---|---|
| Manual synthesis | — | SPE | — | >95% | DOTA-2P(FAPI)2 | 39800373 2025 J Immunother Cancer the precursors were dissolved in 1 mL of NH4OAc (0.25 M aqueous solution) and added to 4 mL of 177LuCl3 solution (0.7 GBq, 0.05 mol/L HCl solution) |
| Manual synthesis | — | SPE | >90% | >95% | DOTA-4P(FAPI)4 | 37321827 2023 J Nucl Med For 177Lu labeling, each of the aforementioned precursors was dissolved in 1 mL of NaAc (0.25 M in water) and added to 4 mL of 177LuCl3 solution (740 MBq in 0.05 M HCl). — 68Ga, 64Cu, and 177Lu were labeled in more than 90% yield with radiochemical purity of more than 95%. |
| Manual synthesis | — | SPE | >90% | >95% | DOTA-2P(FAPI)2 | 37321827 2023 J Nucl Med For 177Lu labeling, each of the aforementioned precursors was dissolved in 1 mL of NaAc (0.25 M in water) and added to 4 mL of 177LuCl3 solution (740 MBq in 0.05 M HCl). — 68Ga, 64Cu, and 177Lu were labeled in more than 90% yield with radiochemical purity of more than 95%. |
| — | — | — | — | >99% | DOTAGA.Glu2.(FAPI)2 | 42448891 2026 Eur J Nucl Med Mol Imaging |
| — | — | — | — | >99% | DOTAGA.PEG2.Glu.(FAPI)2 | 42448891 2026 Eur J Nucl Med Mol Imaging |
| — | — | — | — | — | DOTA-T1-(FAPI)2 | 42343548 2026 J Med Chem |
| — | — | — | — | — | DOTA-2P(FAPI)2 | 41739974 2026 ACS Appl Mater Interfaces |
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Get in touchQuality control Preliminary — inferred from compound class
- Ph. Eur. monograph
- —
- USP monograph
- —
How this set was arrived at. base set per Ph. Eur. general monograph 0125 (rule); radiometal tracer -> metal impurities (rule); Lu-177 preparation -> Lu-177m content (rule); therapeutic radiopharmaceutical -> osmolality (rule); receptor ligand with a saturable target -> molar activity (rule)
Tests listed by reference only. Monograph texts are copyrighted and are not reproduced here. How these are derived
Setting up quality control?We can help you scope the equipment needed to release [177Lu]Lu-FAPI.
Get in touchNotes
Added from reverse module search (stage 6); 2 article(s) with Lu-177. Compound class inferred from precursor name (not stated outright) -- PMID 37321827: 'DOTA-2P(FAPI)2'.