Tracer library / [177Lu]Lu-FAPI

[177Lu]Lu-FAPI

Also written as [177Lu]Lu-FAPI; [Lu-177]Lu-FAPI; FAPI

Radionuclide: Lu-177 t½ 9585 min
Modality: Therapy
Production route: —
Stage: —
Syntheses indexed: 5

Immune cell and immunotherapy imaging Preclinical only, no clinical indication yet FAP-directed radioligand therapy

What it is

Compound class: FAP inhibitor (FAPI) multimer with DOTA chelator
Target / mechanism: Fibroblast activation protein (FAP) targeting PMID 37321827
Clinical application: —
Theranostic pair: [68Ga]Ga-FAPI

Published syntheses

Module	Cassette	Purification	Yield %	RCP %	Precursor / supplier	Source
Manual synthesis	—	SPE	—	>95%	DOTA-2P(FAPI)2	39800373 2025 J Immunother Cancer the precursors were dissolved in 1 mL of NH4OAc (0.25 M aqueous solution) and added to 4 mL of 177LuCl3 solution (0.7 GBq, 0.05 mol/L HCl solution)
Manual synthesis	—	SPE	>90%	>95%	DOTA-4P(FAPI)4	37321827 2023 J Nucl Med For 177Lu labeling, each of the aforementioned precursors was dissolved in 1 mL of NaAc (0.25 M in water) and added to 4 mL of 177LuCl3 solution (740 MBq in 0.05 M HCl). - 68Ga, 64Cu, and 177Lu were labeled in more than 90% yield with radiochemical purity of more than 95%.
Manual synthesis	—	SPE	>90%	>95%	DOTA-2P(FAPI)2	37321827 2023 J Nucl Med For 177Lu labeling, each of the aforementioned precursors was dissolved in 1 mL of NaAc (0.25 M in water) and added to 4 mL of 177LuCl3 solution (740 MBq in 0.05 M HCl). - 68Ga, 64Cu, and 177Lu were labeled in more than 90% yield with radiochemical purity of more than 95%.
—	—	—	—	>99%	DOTAGA.Glu2.(FAPI)2	42448891 2026 Eur J Nucl Med Mol Imaging
—	—	—	—	>99%	DOTAGA.PEG2.Glu.(FAPI)2	42448891 2026 Eur J Nucl Med Mol Imaging

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Quality control Preliminary - inferred from compound class

Ph. Eur. monograph: not verified No Ph. Eur. check is recorded for this entry.
USP monograph: not verified No USP check is recorded for this entry.

AppearancepHRCP HPLCHPLC UVRadionuclidic (HPGe)Half-lifeActivityEndotoxins (LAL)SterilityFilter integrityOsmolalityMolar activityMetal impuritiesLu-177m

How this set was arrived at. base set per Ph. Eur. general monograph 0125 (rule); radiometal tracer -> metal impurities (rule); Lu-177 preparation -> Lu-177m content (rule); therapeutic radiopharmaceutical -> osmolality (rule); receptor ligand with a saturable target -> molar activity (rule)

Tests listed by reference only. Monograph texts are copyrighted and are not reproduced here. How these are derived

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Notes

Added from reverse module search (stage 6); 2 article(s) with Lu-177. Compound class inferred from precursor name (not stated outright) -- PMID 37321827: 'DOTA-2P(FAPI)2'.