Tracer library / [125I]CPCR4.3
[125I]CPCR4.3
Also written as [125I]CPCR4; [I-125]CPCR4; 125I-CPCR4.3; [I-125]CPCR4.3
- Radionuclide
- I-125 t½ 85493 min
- Modality
- —
- Production route
- —
- Stage
- Preclinical
- Syntheses indexed
- 1
What it is
- Compound class
- Pentapeptide ligand (CXCR4-targeting, structurally related to Pentixafor)
- Target / mechanism
- CXCR4 (human and murine) PMID 31410585
- Clinical application
- Preclinical tool for species-independent quantification of CXCR4 expression in murine disease models, including cancer and inflammation PMID 31410585
- Theranostic pair
- —
Published syntheses
| Module | Cassette | Purification | Yield % | RCP % | Precursor / supplier | Source |
|---|---|---|---|---|---|---|
| — | custom manifold | HPLC | — | — | CPCR4.3 (3-iodo-Tyr-analog) | 31410585 2019 EJNMMI Res |
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Get in touchQuality control Preliminary - inferred from compound class
- Ph. Eur. monograph
- not verified No Ph. Eur. check is recorded for this entry.
- USP monograph
- not verified No USP check is recorded for this entry.
How this set was arrived at. base set per Ph. Eur. general monograph 0125 (rule); receptor ligand with a saturable target -> molar activity (rule); organic-phase radiosynthesis assumed from isotope/compound class, no synthesis data confirming it -> GC residual solvents (preliminary)
Tests listed by reference only. Monograph texts are copyrighted and are not reproduced here. How these are derived
Setting up quality control?We can help you scope the equipment needed to release [125I]CPCR4.3.
Get in touchNotes
Added from reverse module search (stage 6); 2 article(s) with I-125. | Stage 30 (2026-09-18): Modality was 'Preclinical (I-125)' -- a stage and an isotope, not a modality. Left empty: PMID 31410585 describes [125I]CPCR4.3 as 'a preclinical tool' for in-vitro and biodistribution work and says its clearance 'will certainly restrict its use for in vivo imaging applications using 123I (for SPECT) or 124I (for PET)'; no imaging or therapy use is stated. Stage set to Preclinical. Open question: that paper's compound is CPCR4.3, a structurally related ligand, not pentixafor itself -- check whether this row's name is right. | Stage 30 (2026-09-18): renamed from '[125I]Pentixafor' (agent_id i125-pentixafor). The two articles behind this row (PMID 31410585, 32724470) describe [125I]CPCR4.3, 'a structurally related pentapeptide ligand' to pentixafor, not radioiodinated pentixafor itself; no corpus article names an '[125I]pentixafor'. Target from PMID 31410585 ('targeting of hCXCR4 and mCXCR4'). The spelling 'PENTIXAFOR' was dropped from the alternative names so a pentixafor search no longer lands here.