Tracer library / [225Ac]Ac-Macropa-pertuzumab-PEG6-DM1
[225Ac]Ac-Macropa-pertuzumab-PEG6-DM1
Also written as [Ac-225]Ac-Macropa-pertuzumab-PEG6-DM1
- Radionuclide
- Ac-225 t½ 14284.8 min
- Modality
- Therapy
- Production route
- —
- Stage
- Preclinical
- Syntheses indexed
- 0
What it is
- Compound class
- Antibody-drug radioconjugate (anti-HER2 antibody-drug conjugate labeled with actinium-225)
- Target / mechanism
- HER2 (human epidermal growth factor receptor 2) PMID 41946831
- Clinical application
- Radioimmunotherapy of HER2-positive breast cancer, including trastuzumab/T-DM1-resistant tumours PMID 41946831
- Theranostic pair
- —
Published syntheses
No synthesis has been parsed for this agent yet.
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Get in touchNotes
Added at stage 22: promoted from 'Reported once' (single-article, no diagnostic pair at discovery) because a full-text synthesis with extracted data exists in parsed-therapy.xlsx -- PMID(s): 41946831. Target/mechanism, clinical application, indications, approval and precursor fields still need per-agent research and are intentionally left empty. Stage set/updated at stage 23 from PMID 41946831: 'Radioimmunotherapy was done in nude mice bearing trastuzumab-resistant HCC1954 (high HER2-density), T-DM1/trastuzumab-resistant JIMT-1 (medium HER2-density) and MDA-MB-468 (negative control with very low HER2-density) xenografts.'.