Tracer library / [67Ga]Comb-2
[67Ga]Comb-2
- Radionuclide
- Ga-67 t½ 4693 min
- Modality
- SPECT
- Production route
- —
- Stage
- Preclinical
- Syntheses indexed
- 1
What it is
- Compound class
- DOTA-conjugated chimeric peptide (DOTA-PEG6-d-PepH3-TPP)
- Target / mechanism
- Membrane-bound heat shock protein 70 (mHsp70) targeting via TPP sequence, with BBB penetration via d-PepH3 sequence PMID 42306550
- Clinical application
- Glioblastoma imaging and therapy PMID 42306550
- Theranostic pair
- —
Published syntheses
| Module | Cassette | Purification | Yield % | RCP % | Precursor / supplier | Source |
|---|---|---|---|---|---|---|
| Manual synthesis | — | HPLC | — | ≥95% | DOTA-PEG6-d-PepH3-TPP (Comb-2) | 42306550 2026 Chem Sci the received [67Ga]gallium-citrate ... was first transformed to [67Ga]GaCl3 by ionic exchange using a Sep-Pak® Classic Silica column |
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Added at stage 22: promoted from 'Reported once' (single-article, no diagnostic pair at discovery) because a full-text synthesis with extracted data exists in parsed-therapy.xlsx -- PMID(s): 42306550. Target/mechanism, clinical application, indications, approval and precursor fields still need per-agent research and are intentionally left empty. | Stage 30 (2026-09-18): Modality was 'Therapy' -- a bucket value given to every agent found by the therapy-oriented bulk search (stages 21-22), not a source statement. Corrected to SPECT: Ga-67 is a gamma emitter used only for SPECT imaging. Linked articles: PMID 42306550. Compound class inferred from precursor name (not stated outright) -- PMID 42306550: 'Comb-2 (DOTA-PEG6-d-PepH3-TPP)'. Stage set/updated at stage 39 from PMID 42306550: 'Biodistribution experiments with 67Ga-labeled compounds were performed in naive female CD1 mice and showed brain uptake at 2 min p.i., as well as renal excretion.'.