Tracer library / [68Ga]DOTA-KiSS-34
[68Ga]DOTA-KiSS-34
- Radionuclide
- Ga-68 t½ 67.71 min
- Modality
- PET
- Production route
- —
- Stage
- Reported once
- Syntheses indexed
- 1
What it is
- Compound class
- DOTA-conjugated KISS1R-targeting peptide (kisspeptin analogue)
- Target / mechanism
- KISS1R (kisspeptin receptor) PMID 41774810
- Clinical application
- Preclinical radiotheranostic (imaging and therapy) tool for KISS1R-positive triple-negative breast cancer PMID 41774810
- Theranostic pair
- [177Lu]Lu-DOTA-KiSS-34
Published syntheses
| Module | Cassette | Purification | Yield % | RCP % | Precursor / supplier | Source |
|---|---|---|---|---|---|---|
| Manual synthesis | — | — | — | 96.1% to 97.8% | DOTA-KiSS-34 | 41774810 2026 Mol Pharm A 5 \u03bcg (1 \u03bcg/\u03bcL) portion of each DOTA-KP was mixed with 30 \u03bcL of sodium acetate (1.14 M), and 300 \u03bcL of 68GaCl3 (50 MBq) was added. |
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Get in touchNotes
Added at stage 22: promoted from 'Reported once' (single-article, no diagnostic pair at discovery) because a full-text synthesis with extracted data exists in parsed-therapy.xlsx -- PMID(s): 41774810. Target/mechanism, clinical application, indications, approval and precursor fields still need per-agent research and are intentionally left empty. Compound class inferred from precursor name (not stated outright) -- PMID 41774810: 'DOTA-KiSS-34'. | Stage 30 (2026-09-18): Modality was 'Therapy' -- a bucket value given to every agent found by the therapy-oriented bulk search (stages 21-22), not a source statement. Corrected to PET: Ga-68 is a positron emitter used only for PET imaging. Linked articles: PMID 41774810.