Tracer library / [123I]PARPi-01

[123I]PARPi-01

Also written as [I-123]PARPi-01

Radionuclide: I-123 t½ 792 min
Modality: Therapy
Production route: —
Stage: Preclinical
Syntheses indexed: 1

Breast cancer Preclinical only, no clinical indication yet

What it is

Compound class: PARP inhibitor (Olaparib derivative)
Target / mechanism: PARP1 (Poly (ADP-ribose)-Polymerase 1) targeting Auger emitter therapy PMID 36104637
Clinical application: SPECT/CT imaging in triple-negative breast cancer xenograft model to guide theranostic Auger emitter therapy PMID 36104637
Theranostic pair: —

Published syntheses

Module	Cassette	Purification	Yield %	RCP %	Precursor / supplier	Source
Manual synthesis	—	HPLC+SPE	78 ± 12%	>95%	Tributyl stannylated derivative of Olaparib	36104637 2022 EJNMMI Res Radiolabelling was conducted as previously described [17] - The resulting overall radiochemical yield was 78 ± 12% with purities of > 95%.

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Notes

Added at stage 22: promoted from 'Reported once' (single-article, no diagnostic pair at discovery) because a full-text synthesis with extracted data exists in parsed-therapy.xlsx -- PMID(s): 36104637. Target/mechanism, clinical application, indications, approval and precursor fields still need per-agent research and are intentionally left empty. Stage set/updated at stage 23 from PMID 36104637: 'In this study, a theranostic approach was investigated in a TNBC xenografted mouse model by radiolabelling a close derivative of a PARPi Olaparib (termed PARPi-01) with the Auger emitters 123/125I.'.