Tracer library / [18F]F-PSMA-617-RESCA
[18F]F-PSMA-617-RESCA
Also written as [18F]F-PSMA-617-RESCA; [F-18]F-PSMA-617-RESCA
- Radionuclide
- F-18 t½ 109.77 min
- Modality
- PET
- Production route
- —
- Stage
- —
- Syntheses indexed
- 2
What it is
- Compound class
- PSMA-617 derivative with RESCA chelator, radiolabelled via [18F]AlF2+ complexation (PSMA-targeting urea-based small molecule)
- Target / mechanism
- PSMA (prostate-specific membrane antigen) PMID 38904859
- Clinical application
- Imaging and therapy of prostate cancer PMID 38904859
- Theranostic pair
- —
Published syntheses
| Module | Cassette | Purification | Yield % | RCP % | Precursor / supplier | Source |
|---|---|---|---|---|---|---|
| AllinOne (AiO) Trasis | custom manifold | SPE | 36 ± 4.9% not corrected | >95% | PSMA-617-RESCA precursor (compound 9) In-house / non-commercial (various) | 38904859 2024 EJNMMI Radiopharm Chem radiosynthesis system Trasis All-in-One - an overall RCY of 36 ± 4.9% (n = 4), non-decay corrected |
| AllinOne (AiO) Trasis | custom manifold | SPE | 36 ± 4.9% not corrected | >95% | PSMA-617-RESCA precursor (compound 9) In-house / non-commercial (various) | 38904859 2024 EJNMMI Radiopharm Chem an automated Trasis All-in-One radiosynthesis module (Additional file 1: Fig. S73) - an overall RCY of 36 ± 4.9% (n = 4), non-decay corrected |
Precursor
- Common precursor
- —
- Suppliers seen in the literature
- —
- Cited suppliers in indexed syntheses
- In-house / non-commercial (various)
- Typical final purification
- —
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Get in touchQuality control Preliminary - inferred from compound class
- Ph. Eur. monograph
- not verified No Ph. Eur. check is recorded for this entry.
- USP monograph
- not verified No USP check is recorded for this entry.
How this set was arrived at. base set per Ph. Eur. general monograph 0125 (rule); receptor ligand with a saturable target -> molar activity (rule); organic-phase radiosynthesis assumed from isotope/compound class, no synthesis data confirming it -> GC residual solvents (preliminary); conventional nucleophilic 18F-fluorination assumed from isotope/compound class, no synthesis data confirming K222 use -> Kryptofix test (preliminary)
Tests listed by reference only. Monograph texts are copyrighted and are not reproduced here. How these are derived
Setting up quality control?We can help you scope the equipment needed to release [18F]F-PSMA-617-RESCA.
Get in touchNotes
Added from reverse module search (stage 6); 3 article(s) with F-18. Compound class inferred from precursor name (not stated outright) -- PMID 38904859: 'precursors 9 (PSMA-617-RESCA precursor)'.