Tracers / [211At]At-astatobenzoate
[211At]At-astatobenzoate
Also written as [At-211]astatobenzoate
- Radionuclide
- At-211 t½ 431 min
- Modality
- Therapy
- Production route
- —
- Stage
- —
- Syntheses indexed
- 3
What it is
- Compound class
- astatobenzoate/astatobenzamide (para-astatobenzoic acid derivative)
- Target / mechanism
- —
- Clinical application
- —
- Theranostic pair
- —
Regulatory status
- FDA
- —
- EMA (centralised)
- —
- Other approvals
- —
- Brand names
- —
Clinical use
- Typical injected activity
- —
- Uptake time
- —
Reported in the literature. Not a dosing recommendation.
Published syntheses
| Module | Cassette | Purification | Yield % | RCP % | Precursor / supplier | Source |
|---|---|---|---|---|---|---|
| — | — | — | — | — | — | 38283213 2024 RSC Med Chem |
| Manual synthesis | — | HPLC | 74 | — | Para-Tri-n-Butylstannylbenzamidyl-dPEG4-Carboxylic Acid Methyl Ester, 9 | 36142567 2022 Int J Mol Sci To a solution containing 100 μg 9 in 100 μL of a 0.05 N HCl MeOH/H2O and 200 μL of a [211At]NaAt solution, pH = 7, ~85 MBq (2.3 mCi), was added 20 μL of a 1 mg/mL aqueous solution of ChT. — a 74% radiochemical yield of [211At]13 by radio-HPLC analysis |
| — | — | — | 70-75% | — | trialkylstannyl precursor | 9234271 1994 Nucl Med Biol |
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Added at stage 21 from therapy-discovered.xlsx (bulk PubMed search by isotope/therapy-type/known-agent, not individually researched yet) -- 9 articles found. Target/mechanism, clinical application, indications, approval and precursor fields still need per-agent research and are intentionally left empty. Compound class inferred from precursor name (not stated outright) -- PMID 36142567: 'Para-Tri-n-Butylstannylbenzamidyl-dPEG4-Carboxylic Acid Methyl Ester, 9'.