Tracer library / [18F]FB-S100s

[18F]FB-S100s

Also written as [18F]FB-S100s; [F-18]FB-S100s

Radionuclide: F-18 t½ 109.77 min
Modality: PET
Production route: —
Stage: Preclinical
Syntheses indexed: 0

Preclinical only, no clinical indication yet

What it is

Compound class: Fluorine-18 labeled S100 protein conjugate (radiolabeled via [18F]SFB, N-succinimidyl 4-[18F]fluorobenzoate)
Target / mechanism: Pattern recognition receptors, e.g., Toll-like receptors (TLRs), the receptor for advanced glycation end products (RAGE), or scavenger receptors (SR) PMID 30710291
Clinical application: Chronic inflammatory conditions, atherosclerosis, cardiomyopathies, neurodegeneration, and cancer progression (rodent disease models) PMID 30710291
Theranostic pair: —

Published syntheses

No synthesis has been parsed for this agent yet.

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Quality control Preliminary - inferred from compound class

Ph. Eur. monograph: not verified No Ph. Eur. check is recorded for this entry.
USP monograph: not verified No USP check is recorded for this entry.

AppearancepHRCP HPLCRCP TLCHPLC UVRadionuclidic (HPGe)Half-lifeActivityEndotoxins (LAL)SterilityFilter integrity

How this set was arrived at. base set per Ph. Eur. general monograph 0125 (rule); organic-phase radiosynthesis assumed from isotope/compound class, no synthesis data confirming it -> GC residual solvents (preliminary); conventional nucleophilic 18F-fluorination assumed from isotope/compound class, no synthesis data confirming K222 use -> Kryptofix test (preliminary)

Tests listed by reference only. Monograph texts are copyrighted and are not reproduced here. How these are derived

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Notes

Added from reverse module search (stage 6); 1 article(s) with F-18.