Tracers / [18F]fluoroacetate

[18F]fluoroacetate

Also written as [18F]fluoroacetate; [F-18]fluoroacetate; Fluoroacetate

Radionuclide: F-18 t½ 109.77 min
Modality: PET
Production route: —
Stage: —
Syntheses indexed: 2

Fibrosis (non-oncologic)Infection imaging Neuroinflammation Hepatobiliary and pancreatic cancer Pan-cancer / multiple tumour types Preclinical only, no clinical indication yet Cerebrovascular disease / cerebral perfusion imaging

What it is

Compound class: 18F-labeled carboxylic acid (fluorinated short-chain fatty acid analog)
Target / mechanism: Aconitase (TCA cycle enzyme) / fatty acid and glial oxidative metabolism PMID 30054282
Clinical application: Liver tumors (hepatocellular carcinoma and metastatic tumors) PMID 24599824
Theranostic pair: —

Regulatory status

FDA: —
EMA (centralised): —
Other approvals: —
Brand names: —

Clinical use

Typical injected activity: —
Uptake time: —

Reported in the literature. Not a dosing recommendation.

Published syntheses

Module	Cassette	Purification	Yield %	RCP %	Precursor / supplier	Source
—	—	—	55% ± 5%	>99%	—	17332620 2007 J Nucl Med
—	—	—	50.2 ± 4.8% yes	>99%	—	16459271 2006 Nucl Med Biol a commercial [(18)F]FDG synthesizer, the TRACERlab MX(FDG) — 50.2 +/- 4.8%, decay corrected

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Quality control Preliminary — inferred from compound class

Ph. Eur. monograph: —
USP monograph: —

AppearancepHRCP HPLCRCP TLCHPLC UVRadionuclidic (HPGe)Half-lifeActivityEndotoxins (LAL)SterilityFilter integrityMolar activity

How this set was arrived at. base set per Ph. Eur. general monograph 0125 (rule); receptor ligand with a saturable target -> molar activity (rule); organic-phase radiosynthesis assumed from isotope/compound class, no synthesis data confirming it -> GC residual solvents (preliminary); conventional nucleophilic 18F-fluorination assumed from isotope/compound class, no synthesis data confirming K222 use -> Kryptofix test (preliminary)

Tests listed by reference only. Monograph texts are copyrighted and are not reproduced here. How these are derived

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Notes

Added from reverse module search (stage 6); 2 article(s) with F-18. | Stage 28: added indication(s) neu-cerebrovascular from consolidated missing-rubric review.