Tracers / [18F]AG-120
[18F]AG-120
Also written as [18F]AG-120; [F-18]AG-120
- Radionuclide
- F-18 t½ 109.77 min
- Modality
- PET
- Production route
- —
- Stage
- preclinical study
- Syntheses indexed
- 1
What it is
- Compound class
- Small-molecule IDH1 inhibitor-based radioligand (AG-120/ivosidenib analog)
- Target / mechanism
- Mutant isocitrate dehydrogenase 1 (IDH1R132H) PMID 37982850
- Clinical application
- —
- Theranostic pair
- —
Regulatory status
- FDA
- —
- EMA (centralised)
- —
- Other approvals
- —
- Brand names
- —
Clinical use
- Typical injected activity
- —
- Uptake time
- —
Reported in the literature. Not a dosing recommendation.
Published syntheses
| Module | Cassette | Purification | Yield % | RCP % | Precursor / supplier | Source |
|---|---|---|---|---|---|---|
| TRACERlab FX2 N GE HealthCare | — | HPLC+SPE | 3.8 ± 0.3% | ≥ 99% | stannyl precursor 6 | 37982850 2024 Eur J Nucl Med Mol Imaging on a TRACERlab FX2 N radiosynthesis module — a radiochemical yield of 3.8 ± 0.3% (n = 9, EOB) |
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Get in touchQuality control Preliminary — inferred from compound class
- Ph. Eur. monograph
- —
- USP monograph
- —
How this set was arrived at. base set per Ph. Eur. general monograph 0125 (rule); organic-phase radiosynthesis assumed from isotope/compound class, no synthesis data confirming it -> GC residual solvents (preliminary); conventional nucleophilic 18F-fluorination assumed from isotope/compound class, no synthesis data confirming K222 use -> Kryptofix test (preliminary)
Tests listed by reference only. Monograph texts are copyrighted and are not reproduced here. How these are derived
Setting up quality control?We can help you scope the equipment needed to release [18F]AG-120.
Get in touchNotes
Added from reverse module search (stage 6); 2 article(s) with F-18. Compound class inferred from precursor name (not stated outright) -- PMID 37982850: 'copper-mediated radiofluorination (CMRF) of the stannyl precursor 6'. Stage set/updated at stage 23 from PMID 37982850: 'Radiosynthesis and biological evaluation of [18F]AG-120 for PET imaging of the mutant isocitrate dehydrogenase 1 in glioma.'.