Tracer library / [18F]AG-120

Structure of AG-120 (unlabelled parent compound, from PubChem) — Unlabelled parent compoundPubChem CID 71657455

[18F]AG-120

Also written as [18F]AG-120; [F-18]AG-120

Radionuclide: F-18 t½ 109.77 min
Modality: PET
Production route: —
Stage: Preclinical
Syntheses indexed: 1

Glioma and brain tumours Preclinical only, no clinical indication yet

What it is

Compound class: Small-molecule IDH1 inhibitor-based radioligand (AG-120/ivosidenib analog)
Target / mechanism: Mutant isocitrate dehydrogenase 1 (IDH1R132H) PMID 37982850
Clinical application: Glioma and IDH1R132H-related tumors PMID 37982850
Theranostic pair: —

Published syntheses

Module	Cassette	Purification	Yield %	RCP %	Precursor / supplier	Source
TRACERlab FX2 N GE HealthCare	—	HPLC+SPE	3.8 ± 0.3%	≥ 99%	stannyl precursor 6	37982850 2024 Eur J Nucl Med Mol Imaging on a TRACERlab FX2 N radiosynthesis module - a radiochemical yield of 3.8 ± 0.3% (n = 9, EOB)

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Quality control Preliminary - inferred from compound class

Ph. Eur. monograph: not verified No Ph. Eur. check is recorded for this entry.
USP monograph: not verified No USP check is recorded for this entry.

AppearancepHRCP HPLCRCP TLCHPLC UVRadionuclidic (HPGe)Half-lifeActivityEndotoxins (LAL)SterilityFilter integrity

How this set was arrived at. base set per Ph. Eur. general monograph 0125 (rule); organic-phase radiosynthesis assumed from isotope/compound class, no synthesis data confirming it -> GC residual solvents (preliminary); conventional nucleophilic 18F-fluorination assumed from isotope/compound class, no synthesis data confirming K222 use -> Kryptofix test (preliminary)

Tests listed by reference only. Monograph texts are copyrighted and are not reproduced here. How these are derived

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Notes

Added from reverse module search (stage 6); 2 article(s) with F-18. Compound class inferred from precursor name (not stated outright) -- PMID 37982850: 'copper-mediated radiofluorination (CMRF) of the stannyl precursor 6'. Stage set/updated at stage 23 from PMID 37982850: 'Radiosynthesis and biological evaluation of [18F]AG-120 for PET imaging of the mutant isocitrate dehydrogenase 1 in glioma.'.