Tracer library / [211At]At-astatophenethylsuccinamate
[211At]At-astatophenethylsuccinamate
Also written as [At-211]astatophenethylsuccinamate
- Radionuclide
- At-211 t½ 431 min
- Modality
- Therapy
- Production route
- —
- Stage
- Preclinical
- Syntheses indexed
- 0
What it is
- Compound class
- N-succinimidyl ester linker reagent for 211At protein/antibody radiolabeling (astatophenethylsuccinamate, SAPS)
- Target / mechanism
- IL-2 receptor alpha-chain (IL-2Ralpha) via humanized anti-Tac antibody PMID 11578907
- Clinical application
- Radioimmunotherapy of cancer using antibody conjugates (e.g., anti-HER2 Herceptin, anti-Tac antibody) in xenograft models PMID 11578907
- Theranostic pair
- —
Published syntheses
No synthesis has been parsed for this agent yet.
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Get in touchNotes
Added at stage 21 from therapy-discovered.xlsx (bulk PubMed search by isotope/therapy-type/known-agent, not individually researched yet) -- 2 articles found. Target/mechanism, clinical application, indications, approval and precursor fields still need per-agent research and are intentionally left empty.