Tracer library / [18F]AlF-NOTA-DV1-k-(DV3)
[18F]AlF-NOTA-DV1-k-(DV3)
Also written as [F-18]AlF-NOTA-DV1-k-(DV3)
- Radionuclide
- F-18 t½ 109.77 min
- Modality
- PET
- Production route
- —
- Stage
- Reported once
- Syntheses indexed
- 1
What it is
- Compound class
- CXCR4-targeting D-peptide-based radiopharmaceutical (NOTA-conjugated)
- Target / mechanism
- CXCR4 (C-X-C chemokine receptor 4) PMID 34683912
- Clinical application
- CXCR4-targeted molecular imaging and radionuclide therapy (patient selection for CXCR4-directed therapy) PMID 34683912
- Theranostic pair
- —
Published syntheses
| Module | Cassette | Purification | Yield % | RCP % | Precursor / supplier | Source |
|---|---|---|---|---|---|---|
| AllinOne (AiO) Trasis | vendor cassette | HPLC | 26 ± 6% decay-corrected | >98% | NOTA-DV1-k-(DV3) Pepmic Co., Ltd., Suzhou, China | 34683912 2021 Pharmaceutics NOTA-DV1-k-(DV3) was labeled using the Al18F-method in an AllInOne® synthesis module (Trasis, Ans, Belgium) [17]. - [18F]AlF-NOTA-DV1-k-(DV3) was successfully produced in high yield (26 ± 6% (decay-corrected, activity in reactor/activity final batch of purified product, n = 6) |
Precursor
- Common precursor
- —
- Suppliers seen in the literature
- —
- Cited suppliers in indexed syntheses
- Pepmic Co., Ltd.
- Typical final purification
- —
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Get in touchNotes
Added at stage 22: promoted from 'Reported once' (single-article, no diagnostic pair at discovery) because a full-text synthesis with extracted data exists in parsed-therapy.xlsx -- PMID(s): 34683912. Target/mechanism, clinical application, indications, approval and precursor fields still need per-agent research and are intentionally left empty. Compound class inferred from precursor name (not stated outright) -- PMID 34683912: 'NOTA-DV1-k-(DV3)'. | Stage 26: Name corrected from '[18F]AlF-NOTA-DV1-k-(DV3' to '[18F]AlF-NOTA-DV1-k-(DV3)' -- matches the precursor name already on file from PMID 34683912 ('NOTA-DV1-k-(DV3)'): missing closing parenthesis restored. | Stage 30 (2026-09-18): Modality was 'Therapy' -- a bucket value given to every agent found by the therapy-oriented bulk search (stages 21-22), not a source statement. Corrected to PET: F-18 is a positron emitter used only for PET imaging. Linked articles: PMID 34683912.