[89Zr]PEG-Nb159

Radionuclide: Zr-89 t½ 4704 min
Modality: PET
Production route: —
Stage: Reported once
Syntheses indexed: 1

Pan-cancer / multiple tumour types Preclinical only, no clinical indication yet Fibroblast activation / tumour stroma

What it is

Compound class: FAP-targeting nanobody conjugated with DFO and PEG
Target / mechanism: Fibroblast activation protein (FAP) PMID 41460404
Clinical application: PET imaging companion diagnostic for FAP-targeted radiotheranostics, preclinical mouse tumor model PMID 41460404
Theranostic pair: [177Lu]Lu-PEG-Nb159

Published syntheses

Module	Cassette	Purification	Yield %	RCP %	Precursor / supplier	Source
Manual synthesis	—	SPE	—	—	PEG-DFO-Nb159	41460404 2025 EJNMMI Radiopharm Chem 111 MBq of 89Zr-oxalate solution (3D Imaging) was diluted with 300 µl of 1 M HEPES and added to 200 µl of DFO-functionalized Nb (1–2 mg) in HEPES/NaCl buffer (pH 7.5), adjusted to pH 6.8–7.5, and incubated for 1 h at room temperature.

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Notes

Added at stage 22: promoted from 'Reported once' (single-article, no diagnostic pair at discovery) because a full-text synthesis with extracted data exists in parsed-therapy.xlsx -- PMID(s): 41460404. Target/mechanism, clinical application, indications, approval and precursor fields still need per-agent research and are intentionally left empty. Compound class inferred from precursor name (not stated outright) -- PMID 41460404: 'PEG-DFO-Nb159'. | Stage 30 (2026-09-18): Modality was 'Therapy' -- a bucket value given to every agent found by the therapy-oriented bulk search (stages 21-22), not a source statement. Corrected to PET: Zr-89 is a positron emitter used only for PET imaging. Linked articles: PMID 41460404.