Tracer library / [67Cu]Cu-SarAr-PEG10-Tz
[67Cu]Cu-SarAr-PEG10-Tz
Also written as [Cu-67]Cu-SarAr-PEG10-Tz
- Radionuclide
- Cu-67 t½ 3708 min
- Modality
- Therapy
- Production route
- —
- Stage
- Preclinical
- Syntheses indexed
- 1
What it is
- Compound class
- Sarcophagine-tetrazine (SarAr-PEG10-Tz) radioligand for pretargeted IEDDA click chemistry
- Target / mechanism
- Tetrazine-trans-cyclooctene inverse electron-demand Diels-Alder (IEDDA) ligation for pretargeting a TCO-bearing anti-A33 antibody (huA33-TCO) PMID 41605863
- Clinical application
- Colorectal cancer, pretargeted radioimmunotherapy PMID 41605863
- Theranostic pair
- [64Cu]SarAr-PEG10-Tz
Published syntheses
| Module | Cassette | Purification | Yield % | RCP % | Precursor / supplier | Source |
|---|---|---|---|---|---|---|
| Manual synthesis | — | none | >99% | >99% | SarAr-PEG10-Tz | 41605863 2026 Mol Pharm we first optimized the radiolabeling of SarAr-PEG10-Tz with [67Cu]fCuCl2 - >99% radiochemical conversion |
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Get in touchNotes
Added at stage 22: promoted from 'Reported once' (single-article, no diagnostic pair at discovery) because a full-text synthesis with extracted data exists in parsed-therapy.xlsx -- PMID(s): 41605863. Target/mechanism, clinical application, indications, approval and precursor fields still need per-agent research and are intentionally left empty. Compound class inferred from precursor name (not stated outright) -- PMID 41605863: 'SarAr-PEG10-Tz'. Stage set/updated at stage 39 from PMID 41605863: 'pretargeted radioimmunotherapy with [67Cu]Cu-SarAr-PEG10-Tz exhibits promising efficacy and safety in a murine model of colorectal cancer'.