Tracer library / [68Ga]AAZTA-FAPI-46
[68Ga]AAZTA-FAPI-46
Also written as [Ga-68]Ga-AAZTA-FAPI-46
- Radionuclide
- Ga-68 t½ 67.71 min
- Modality
- PET
- Production route
- —
- Stage
- Preclinical
- Syntheses indexed
- 2
What it is
- Compound class
- AAZTA-conjugated FAP inhibitor (FAPI-46-derived)
- Target / mechanism
- Fibroblast activation protein (FAP) inhibitor targeting FAP-expressing tumor stroma PMID 40762892
- Clinical application
- —
- Theranostic pair
- —
Published syntheses
| Module | Cassette | Purification | Yield % | RCP % | Precursor / supplier | Source |
|---|---|---|---|---|---|---|
| Scintomics GallElut Scintomics | custom manifold | SPE | 84.97 ± 1.37% | >98% | AAZTA-FAPI-46 | 40762892 2025 EJNMMI Radiopharm Chem The preparation of [68Ga]Ga-AAZTA-FAPI-46 was automated on a GallElut+ system (Scintomics, Germany). - The radiochemical yield was 84.97 ± 1.37%. |
| Manual synthesis | — | SPE | — | >98% | AAZTA-FAPI-46 | 40762892 2025 EJNMMI Radiopharm Chem Gallium-68 manual radiolabelling |
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Get in touchNotes
Added at stage 22: promoted from 'Reported once' (single-article, no diagnostic pair at discovery) because a full-text synthesis with extracted data exists in parsed-therapy.xlsx -- PMID(s): 40762892. Target/mechanism, clinical application, indications, approval and precursor fields still need per-agent research and are intentionally left empty. Compound class inferred from precursor name (not stated outright) -- PMID 40762892: 'AAZTA-FAPI-46'. Stage set/updated at stage 23 from PMID 40762892: 'Preclinical evaluation of [68Ga]Ga-AAZTA-FAPI-46: a novel PET tracer for targeting fibroblast activation protein (FAP).'. | Stage 30 (2026-09-18): Modality was 'Therapy' -- a bucket value given to every agent found by the therapy-oriented bulk search (stages 21-22), not a source statement. Corrected to PET: Ga-68 is a positron emitter used only for PET imaging. Linked articles: PMID 40762892.