Tracer library / [86Y]pepa-pic2-C-Hex-KuE

[86Y]pepa-pic2-C-Hex-KuE

Radionuclide: Y-86 t½ 884.4 min
Modality: PET
Production route: —
Stage: Reported once
Syntheses indexed: 1

Prostate cancer Preclinical only, no clinical indication yet

What it is

Compound class: PSMA-targeting urea-based small molecule (C-Hex-KuE) conjugated to pepa-pic2 chelator
Target / mechanism: Prostate-specific membrane antigen (PSMA) PMID 41324598
Clinical application: Prostate cancer imaging (preclinical) PMID 41324598
Theranostic pair: —

Published syntheses

Module	Cassette	Purification	Yield %	RCP %	Precursor / supplier	Source
Manual synthesis	—	none	—	>98%	pepa-pic2-C-Hex-KuE	41324598 2025 J Am Chem Soc Radiolabeling to afford [86Y]Y-pepa-pic2-C-hex-KuE was performed under conditions similar to those used for the nontargeted chelators evaluated in the naïve biodistribution studies - the resulting complex was obtained with a high radiochemical yield

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Notes

Added at stage 22: promoted from 'Reported once' (single-article, no diagnostic pair at discovery) because a full-text synthesis with extracted data exists in parsed-therapy.xlsx -- PMID(s): 41324598. Target/mechanism, clinical application, indications, approval and precursor fields still need per-agent research and are intentionally left empty. Compound class inferred from precursor name (not stated outright) -- PMID 41324598: 'pepa-pic2-C-hex-KuE'. | Stage 30 (2026-09-18): Modality was 'Therapy' -- a bucket value given to every agent found by the therapy-oriented bulk search (stages 21-22), not a source statement. Corrected to PET: Y-86 is a positron emitter used only for PET imaging. Linked articles: PMID 41324598.