Tracers / [86Y]pepa-pic2-C-Hex-KuE
[86Y]pepa-pic2-C-Hex-KuE
- Radionuclide
- Y-86 t½ 884.4 min
- Modality
- Therapy
- Production route
- —
- Stage
- Reported once
- Syntheses indexed
- 1
What it is
- Compound class
- PSMA-targeting urea-based small molecule (C-Hex-KuE) conjugated to pepa-pic2 chelator
- Target / mechanism
- Prostate-specific membrane antigen (PSMA) PMID 41324598
- Clinical application
- —
- Theranostic pair
- —
Regulatory status
- FDA
- —
- EMA (centralised)
- —
- Other approvals
- —
- Brand names
- —
Clinical use
- Typical injected activity
- —
- Uptake time
- —
Reported in the literature. Not a dosing recommendation.
Published syntheses
| Module | Cassette | Purification | Yield % | RCP % | Precursor / supplier | Source |
|---|---|---|---|---|---|---|
| Manual synthesis | — | none | — | >98% | pepa-pic2-C-Hex-KuE | 41324598 2025 J Am Chem Soc Radiolabeling to afford [86Y]Y-pepa-pic2-C-hex-KuE was performed under conditions similar to those used for the nontargeted chelators evaluated in the naïve biodistribution studies — the resulting complex was obtained with a high radiochemical yield |
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Added at stage 22: promoted from 'Reported once' (single-article, no diagnostic pair at discovery) because a full-text synthesis with extracted data exists in parsed-therapy.xlsx -- PMID(s): 41324598. Target/mechanism, clinical application, indications, approval and precursor fields still need per-agent research and are intentionally left empty. Compound class inferred from precursor name (not stated outright) -- PMID 41324598: 'pepa-pic2-C-hex-KuE'.