Tracer library / [68Ga]NOTA-A1-His

[68Ga]NOTA-A1-His

Also written as [Ga-68]Ga-NOTA-A1-His

Radionuclide: Ga-68 t½ 67.71 min
Modality: PET
Production route: —
Stage: Preclinical
Syntheses indexed: 1

Preclinical only, no clinical indication yet

What it is

Compound class: NOTA-conjugated anti-mesothelin single-domain antibody (nanobody)
Target / mechanism: Mesothelin PMID 40833585
Clinical application: PET imaging of mesothelin-expressing tumors (mesothelin-overexpressing cancers) PMID 40833585
Theranostic pair: —

Published syntheses

Module	Cassette	Purification	Yield %	RCP %	Precursor / supplier	Source
Manual synthesis	—	SPE	—	98 ± 1%	p-SCN-Bn-NOTA-A1-His	40833585 2025 EJNMMI Radiopharm Chem 100 µg of DOTA- or NOTA-conjugated A1-His (7 nmoles) in 1 M ammonium acetate were added to Ga-68 eluate (145–222 MBq).

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Notes

Added at stage 22: promoted from 'Reported once' (single-article, no diagnostic pair at discovery) because a full-text synthesis with extracted data exists in parsed-therapy.xlsx -- PMID(s): 40833585. Target/mechanism, clinical application, indications, approval and precursor fields still need per-agent research and are intentionally left empty. Compound class inferred from precursor name (not stated outright) -- PMID 40833585: 'p-SCN-Bn-NOTA-A1-His'. Stage set/updated at stage 23 from PMID 40833585: 'Biodistribution and imaging studies in mice bearing mesothelin-expressing tumors showed specific tumor targeting for both tracers.'. | Stage 30 (2026-09-18): Modality was 'Therapy' -- a bucket value given to every agent found by the therapy-oriented bulk search (stages 21-22), not a source statement. Corrected to PET: Ga-68 is a positron emitter used only for PET imaging. Linked articles: PMID 40833585.