Tracer library / [18F]mBPET-1

[18F]mBPET-1

Also written as [18F]mBPET-1; [F-18]mBPET-1

Radionuclide: F-18 t½ 109.77 min
Modality: PET
Production route: —
Stage: —
Syntheses indexed: 1

Breast cancer Preclinical only, no clinical indication yet

What it is

Compound class: Benzofuran-based mTOR inhibitor derivative
Target / mechanism: mTOR kinase (mTORC1) inhibitor-based probe PMID 31974638
Clinical application: HER2 positive breast cancer, identifying patients receptive to RAD001 (mTOR inhibitor) combination therapy PMID 31974638
Theranostic pair: —

Published syntheses

Module	Cassette	Purification	Yield %	RCP %	Precursor / supplier	Source
iPHASE FlexLab iPHASE Technologies	custom manifold	HPLC+SPE	40% ± 5%	≥99%	alkyne precursor 5 /…alkyne precursor 5 / 2-azidoethyl-4-toluenesulfonate	31974638 2020 EJNMMI Radiopharm Chem automated on an iPhase FlexLab synthesis module - The overall radiochemical yield (RCY) of [18F]mBPET-1 was 40% ± 5% (n = 6) after 90 min.

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Quality control Preliminary - inferred from compound class

Ph. Eur. monograph: not verified No Ph. Eur. check is recorded for this entry.
USP monograph: not verified No USP check is recorded for this entry.

AppearancepHRCP HPLCRCP TLCHPLC UVRadionuclidic (HPGe)Half-lifeActivityEndotoxins (LAL)SterilityFilter integrity

How this set was arrived at. base set per Ph. Eur. general monograph 0125 (rule); organic-phase radiosynthesis assumed from isotope/compound class, no synthesis data confirming it -> GC residual solvents (preliminary); conventional nucleophilic 18F-fluorination assumed from isotope/compound class, no synthesis data confirming K222 use -> Kryptofix test (preliminary)

Tests listed by reference only. Monograph texts are copyrighted and are not reproduced here. How these are derived

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Notes

Added from reverse module search (stage 6); 1 article(s) with F-18.