Tracer library / [18F]FBEM-Cys-H4
[18F]FBEM-Cys-H4
Also written as [18F]FBEM-Cys-H4; [F-18]FBEM-Cys-H4
- Radionuclide
- F-18 t½ 109.77 min
- Modality
- PET
- Production route
- —
- Stage
- Preclinical
- Syntheses indexed
- 1
What it is
- Compound class
- Nanofitin (Sac7d-derived protein scaffold) labelled via cysteine-maleimide conjugation
- Target / mechanism
- hen egg white lysozyme PMID 28575696
- Clinical application
- —
- Theranostic pair
- —
Published syntheses
| Module | Cassette | Purification | Yield % | RCP % | Precursor / supplier | Source |
|---|---|---|---|---|---|---|
| FASTlab GE HealthCare | — | HPLC | 54±7% decay-corrected | — | Cys-H4 Nanofitin | 28575696 2017 Nucl Med Biol The synthesis of [18F]FBEM has been completely implemented on a radiosynthesis unit (FastLab) including HPLC purification and formulation. - Radiochemical yield (decay corrected) of 54±7% (n=4) was obtained after optimization for coupling the [18F]FBEM to Nanofitin. |
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Get in touchQuality control Preliminary - inferred from compound class
- Ph. Eur. monograph
- not verified No Ph. Eur. check is recorded for this entry.
- USP monograph
- not verified No USP check is recorded for this entry.
How this set was arrived at. base set per Ph. Eur. general monograph 0125 (rule); organic-phase radiosynthesis assumed from isotope/compound class, no synthesis data confirming it -> GC residual solvents (preliminary); conventional nucleophilic 18F-fluorination assumed from isotope/compound class, no synthesis data confirming K222 use -> Kryptofix test (preliminary)
Tests listed by reference only. Monograph texts are copyrighted and are not reproduced here. How these are derived
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Get in touchNotes
Added from reverse module search (stage 6); 1 article(s) with F-18. Compound class inferred from precursor name (not stated outright) -- PMID 28575696: 'A single cysteine residue has been genetically inserted in a model Nanofitin and its regioselective radiolabelling has been performed with 4-[18F]fluorobenzamido-N-ethylamino-maleimide ([18F]FBEM).'. Stage set/updated at stage 39 from PMID 28575696: 'PET-MRI studies on C57BL/6 mice were conducted after injection of [18F]FBEM-Cys-H4 in order to access the biodistribution of this Nanofitin model.'.