Tracers / [18F]JMV5763

[18F]JMV5763

Also written as [18F]JMV5763; [F-18]JMV5763

Radionuclide: F-18 t½ 109.77 min
Modality: PET
Production route: —
Stage: —
Syntheses indexed: 1

Preclinical only, no clinical indication yet

What it is

Compound class: NODA-MPAA functionalized JMV5763, a short analog of TLQP-21 neuropeptide
Target / mechanism: —
Clinical application: —
Theranostic pair: —

Regulatory status

FDA: —
EMA (centralised): —
Other approvals: —
Brand names: —

Clinical use

Typical injected activity: —
Uptake time: —

Reported in the literature. Not a dosing recommendation.

Published syntheses

Module	Cassette	Purification	Yield %	RCP %	Precursor / supplier	Source
TRACERlab FX N Pro GE HealthCare	custom manifold	SPE	33.8 ± 2% no	99.0 ± 5%	NODA-MPAA functionalized JMV5763 CheMatech (Dijon, France) [chelator]; synthesized in-house [peptide]	30542281 2018 Front Pharmacol fully automated using a GE TRACERlab FX-N Pro synthesis module — Radiochemical yield, not corrected for decay, was of 33.8 ± 2%.

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Quality control Preliminary — inferred from compound class

Ph. Eur. monograph: —
USP monograph: —

AppearancepHRCP HPLCRCP TLCHPLC UVRadionuclidic (HPGe)Half-lifeActivityEndotoxins (LAL)SterilityFilter integrity

How this set was arrived at. base set per Ph. Eur. general monograph 0125 (rule); organic-phase radiosynthesis assumed from isotope/compound class, no synthesis data confirming it -> GC residual solvents (preliminary); conventional nucleophilic 18F-fluorination assumed from isotope/compound class, no synthesis data confirming K222 use -> Kryptofix test (preliminary)

Tests listed by reference only. Monograph texts are copyrighted and are not reproduced here. How these are derived

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Notes

Added from reverse module search (stage 6); 1 article(s) with F-18. Compound class inferred from precursor name (not stated outright) -- PMID 30542281: 'NODA-MPAA functionalized JMV5763'.