Tracer library / [64Cu]Pep-1L
[64Cu]Pep-1L
Also written as [Cu-64]Pep-1L
- Radionuclide
- Cu-64 t½ 762 min
- Modality
- PET
- Production route
- —
- Stage
- Preclinical
- Syntheses indexed
- 1
What it is
- Compound class
- NOTA-conjugated peptide (IL13RA2-targeted peptide, Pep-1L)
- Target / mechanism
- IL13RA2 (interleukin 13 receptor alpha 2) targeted peptide PMID 28562337
- Clinical application
- Glioblastoma (GBM) PMID 28562337
- Theranostic pair
- [225Ac]Ac-Pep-1L
Published syntheses
| Module | Cassette | Purification | Yield % | RCP % | Precursor / supplier | Source |
|---|---|---|---|---|---|---|
| Manual synthesis | — | — | — | >98% | NOTA-Pep-1L CPC Scientific, San Jose, CA | 28562337 2017 Oncotarget Both the peptides, Pep-1L and scrambled peptide-NOTA were radiolabeled with Cu-64 according to the previously reported methods |
Precursor
- Common precursor
- —
- Suppliers seen in the literature
- —
- Cited suppliers in indexed syntheses
- CPC Scientific
- Typical final purification
- —
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Get in touchNotes
Added at stage 22: promoted from 'Reported once' (single-article, no diagnostic pair at discovery) because a full-text synthesis with extracted data exists in parsed-therapy.xlsx -- PMID(s): 28562337. Target/mechanism, clinical application, indications, approval and precursor fields still need per-agent research and are intentionally left empty. Compound class inferred from precursor name (not stated outright) -- PMID 28562337: 'NOTA-Pep-1L'. | Stage 30 (2026-09-18): Modality was 'Therapy' -- a bucket value given to every agent found by the therapy-oriented bulk search (stages 21-22), not a source statement. Corrected to PET: Cu-64 agent whose theranostic partner ac225-pep1l carries the therapy isotope Ac-225: this is the imaging half of the pair. Linked articles: PMID 28562337. Stage set/updated at stage 39 from PMID 28562337: 'we demonstrated real-time GBM localization of [64Cu]Pep-1L to orthotopic GBMs using small animal PET imaging'.