Tracer library / [225Ac]Ac-3p-C-DEPA-NO2
[225Ac]Ac-3p-C-DEPA-NO2
Also written as [Ac-225]Ac-3p-C-DEPA-NO2
- Radionuclide
- Ac-225 t½ 14284.8 min
- Modality
- Therapy
- Production route
- —
- Stage
- Preclinical
- Syntheses indexed
- 1
What it is
- Compound class
- DEPA-based bifunctional chelator (decadentate macrocyclic ligand) for radiometal labelling
- Target / mechanism
- —
- Clinical application
- —
- Theranostic pair
- —
Published syntheses
| Module | Cassette | Purification | Yield % | RCP % | Precursor / supplier | Source |
|---|---|---|---|---|---|---|
| Manual synthesis | — | SPE | 93.7 to 96.8% | — | 3p-C-DEPA-NO2 | 41428153 2025 EJNMMI Radiopharm Chem The radiolabelling experiments were performed by reacting 90–100 kBq of [225Ac]Ac(NO3)3 - Excellent radiochemical conversions (RCCs) were achieved for [225Ac]Ac-3p-C-DEPA-NO2 across a range of concentrations (0.7- 13.4 µg) with high RCC’s (93.7 to 96.8%) after 1 h at room temperature. |
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Added at stage 22: promoted from 'Reported once' (single-article, no diagnostic pair at discovery) because a full-text synthesis with extracted data exists in parsed-therapy.xlsx -- PMID(s): 41428153. Target/mechanism, clinical application, indications, approval and precursor fields still need per-agent research and are intentionally left empty. Compound class inferred from precursor name (not stated outright) -- PMID 41428153: '3p-C-DEPA-NO2 (1, 2- [(carboxymethyl)] [5-(4-nitrophenyl-1-[4, 7, 10-tris(carboxymethyl) -1, 4, 7, 10- tetraazacyclododecan-1-yl]pentan-2-yl)amino]acetic acid), is a decadentate ligand'. Stage set/updated at stage 23 from PMID 41428153: 'Preclinical characterization of 3p-C-DEPA-NCS and 3p-C-DEPA-TFP-PEG4 as potential Actinium-225 bifunctional chelators using DOTA-NCS and macropa-NCS as benchmarks.'.