Tracers / [18F]FSO3-PSMA

[18F]FSO3-PSMA

Also written as [18F]FSO3-PSMA; [F-18]FSO3-PSMA
Radionuclide
F-18 t½ 109.7 min
Modality
PET
Production route
Cyclotron liquid target
Stage
Research
Syntheses indexed
0
Prostate cancerPreclinical only, no clinical indication yet

What it is

Compound class
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Target / mechanism
Prostate-specific membrane antigen (PSMA); PSMA ligand bearing an aryl fluorosulfate (-OSO2F) group labelled by 18F/19F sulfur-fluoride exchange (SuFEx) PMID 38749342 / DOI 10.1016/j.bmc.2024.117733
Clinical application
(preclinical/research) PET imaging of PSMA-positive prostate cancer PMID 38749342 / DOI 10.1016/j.bmc.2024.117733
Theranostic pair
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Regulatory status

FDA
No Drugs@FDA / openFDA drug registry — no approved application found; search: https://www.accessdata.fda.gov/scripts/cder/daf/index.cfm?event=BasicSearch.process&searchTerm=fluorosulfate+PSMA
EMA (centralised)
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Other approvals
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Brand names
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Clinical use

Typical injected activity
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Uptake time
—

Reported in the literature. Not a dosing recommendation.

Published syntheses

No synthesis has been parsed for this agent yet.

Precursor

Common precursor
Aryl fluorosulfate (Ar-OSO2F)-bearing PSMA ligand; labelled by SuFEx 18F-for-19F isotopic exchange (no separate leaving-group precursor) PMC10520611 (EJNMMI Radiopharm Chem 2023)
Suppliers seen in the literature
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Typical final purification
HPLC

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Quality control Preliminary — inferred from compound class

Ph. Eur. monograph
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USP monograph
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AppearancepHRCP HPLCRCP TLCHPLC UVRadionuclidic (HPGe)Half-lifeActivityEndotoxins (LAL)SterilityFilter integrityMolar activity
How this set was arrived at. base set per Ph. Eur. general monograph 0125 (rule); receptor ligand with a saturable target -> molar activity (rule); organic-phase radiosynthesis assumed from isotope/compound class, no synthesis data confirming it -> GC residual solvents (preliminary); conventional nucleophilic 18F-fluorination assumed from isotope/compound class, no synthesis data confirming K222 use -> Kryptofix test (preliminary)

Tests listed by reference only. Monograph texts are copyrighted and are not reproduced here. How these are derived

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Notes

Target and application not filled - to be taken from the publication.