Tracers / [18F]AQ28A
[18F]AQ28A
Also written as [18F]AQ28A; [F-18]AQ28A
- Radionuclide
- F-18 t½ 109.77 min
- Modality
- PET
- Production route
- —
- Stage
- preclinical
- Syntheses indexed
- 1
What it is
- Compound class
- 8-bromo-1-(6-[18F]fluoropyridin-3-yl)-3,4-dimethylimidazo[1,5-a]quinoxaline radioligand
- Target / mechanism
- Phosphodiesterase 10A (PDE10A) PMID 27896836
- Clinical application
- Neurodegenerative and psychiatric diseases (preclinical brain imaging) PMID 27896836
- Theranostic pair
- —
Regulatory status
- FDA
- —
- EMA (centralised)
- —
- Other approvals
- —
- Brand names
- —
Clinical use
- Typical injected activity
- —
- Uptake time
- —
Reported in the literature. Not a dosing recommendation.
Published syntheses
| Module | Cassette | Purification | Yield % | RCP % | Precursor / supplier | Source |
|---|---|---|---|---|---|---|
| — | — | — | 33 ± 6% | — | nitro precursor | 27896836 2017 J Labelled Comp Radiopharm we developed an automated synthesis on a Tracerlab FX F-N module — [18 F]AQ28A with high radiochemical yields (33 ± 6%) |
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Get in touchQuality control Preliminary — inferred from compound class
- Ph. Eur. monograph
- —
- USP monograph
- —
How this set was arrived at. base set per Ph. Eur. general monograph 0125 (rule); receptor ligand with a saturable target -> molar activity (rule); organic-phase radiosynthesis assumed from isotope/compound class, no synthesis data confirming it -> GC residual solvents (preliminary); conventional nucleophilic 18F-fluorination assumed from isotope/compound class, no synthesis data confirming K222 use -> Kryptofix test (preliminary)
Tests listed by reference only. Monograph texts are copyrighted and are not reproduced here. How these are derived
Setting up quality control?We can help you scope the equipment needed to release [18F]AQ28A.
Get in touchNotes
Added from reverse module search (stage 6); 1 article(s) with F-18.