Tracer library / [18F]AQ28A

[18F]AQ28A

Also written as [18F]AQ28A; [F-18]AQ28A

Radionuclide: F-18 t½ 109.77 min
Modality: PET
Production route: —
Stage: Preclinical
Syntheses indexed: 1

CNS receptor and transporter imaging Preclinical only, no clinical indication yet

What it is

Compound class: 8-bromo-1-(6-[18F]fluoropyridin-3-yl)-3,4-dimethylimidazo[1,5-a]quinoxaline radioligand
Target / mechanism: Phosphodiesterase 10A (PDE10A) PMID 27896836
Clinical application: Neurodegenerative and psychiatric diseases (preclinical brain imaging) PMID 27896836
Theranostic pair: —

Published syntheses

Module	Cassette	Purification	Yield %	RCP %	Precursor / supplier	Source
TRACERlab FX FN GE HealthCare	—	—	33 ± 6%	—	nitro precursor	27896836 2017 J Labelled Comp Radiopharm we developed an automated synthesis on a Tracerlab FX F-N module - [18 F]AQ28A with high radiochemical yields (33 ± 6%)

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Quality control Preliminary - inferred from compound class

Ph. Eur. monograph: not verified No Ph. Eur. check is recorded for this entry.
USP monograph: not verified No USP check is recorded for this entry.

AppearancepHRCP HPLCRCP TLCHPLC UVRadionuclidic (HPGe)Half-lifeActivityEndotoxins (LAL)SterilityFilter integrityMolar activity

How this set was arrived at. base set per Ph. Eur. general monograph 0125 (rule); receptor ligand with a saturable target -> molar activity (rule); organic-phase radiosynthesis assumed from isotope/compound class, no synthesis data confirming it -> GC residual solvents (preliminary); conventional nucleophilic 18F-fluorination assumed from isotope/compound class, no synthesis data confirming K222 use -> Kryptofix test (preliminary)

Tests listed by reference only. Monograph texts are copyrighted and are not reproduced here. How these are derived

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Notes

Added from reverse module search (stage 6); 1 article(s) with F-18.