Tracers / [68Ga]LW02080
[68Ga]LW02080
Also written as [Ga-68]Ga-LW02080
- Radionuclide
- Ga-68 t½ 67.71 min
- Modality
- Therapy
- Production route
- —
- Stage
- Reported once
- Syntheses indexed
- 1
What it is
- Compound class
- DOTA-conjugated bombesin(6-14) peptide analog (GRPR antagonist)
- Target / mechanism
- Gastrin-releasing peptide receptor (GRPR) antagonist PMID 40006047
- Clinical application
- Preclinical PET imaging of GRPR-expressing tumors (PC-3 xenografts) in mice PMID 40006047
- Theranostic pair
- <a href="/tracers/lu177-lw02080/">lu177-lw02080</a>
Regulatory status
- FDA
- —
- EMA (centralised)
- —
- Other approvals
- —
- Brand names
- —
Clinical use
- Typical injected activity
- —
- Uptake time
- —
Reported in the literature. Not a dosing recommendation.
Published syntheses
| Module | Cassette | Purification | Yield % | RCP % | Precursor / supplier | Source |
|---|---|---|---|---|---|---|
| Manual synthesis | custom manifold | HPLC+SPE | 41–75% yes | >95% | LW02080 (DOTA-conjugated peptide) | 40006047 2025 Pharmaceuticals (Basel) purified 68Ga (158–523 MBq) in 0.5 mL water was added into a 4-mL glass vial containing 0.7 mL of HEPES buffer (2 M, pH 5.0) and 10 μL of precursor solution (1 mM). The radiolabeling reaction was performed by microwave heating for 1 min at 100 °C, followed by purification using HPLC with a semi-preparative column. — 68Ga-labeled LW02060 and LW02080 were obtained in 41–75% decay-corrected radiochemical yields with >172 GBq/µmol molar activity and >95% radiochemical purity |
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Added at stage 22: promoted from 'Reported once' (single-article, no diagnostic pair at discovery) because a full-text synthesis with extracted data exists in parsed-therapy.xlsx -- PMID(s): 40006047. Target/mechanism, clinical application, indications, approval and precursor fields still need per-agent research and are intentionally left empty.