Tracers / [99mTc]Tc(CO)3-NOTA-AocNle-CycMSHhex

[99mTc]Tc(CO)3-NOTA-AocNle-CycMSHhex

Also written as [Tc-99m]Tc(CO)3-NOTA-AocNle-CycMSHhex
Radionuclide
Tc-99m t½ 360.6 min
Modality
Therapy
Production route
—
Stage
Reported once
Syntheses indexed
1
MelanomaPreclinical only, no clinical indication yet

What it is

Compound class
NOTA-conjugated lactam-cyclized α-MSH peptide (MC1R-targeting peptide)
Target / mechanism
MC1R (melanocortin 1 receptor)-specific binding on melanoma cells PMID 37140963
Clinical application
Melanoma imaging PMID 37140963
Theranostic pair
—

Regulatory status

FDA
—
EMA (centralised)
—
Other approvals
—
Brand names
—

Clinical use

Typical injected activity
—
Uptake time
—

Reported in the literature. Not a dosing recommendation.

Published syntheses

ModuleCassettePurificationYield %RCP %Precursor / supplierSource
Kit-based preparation
Mallinckrodt
vendor cassetteHPLC>90%>95%NOTA-AocNle-CycMSHhex37140963
2023 Bioconjug Chem
prepared using IsoLink kit — [99mTc]Tc(CO)3-NOTA-PEG2Nle-CycMSHhex and [99mTc]Tc(CO)3-NOTA-AocNle-CycMSHhex were readily prepared with more than 90% radiochemical yields

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Notes

Added at stage 22: promoted from 'Reported once' (single-article, no diagnostic pair at discovery) because a full-text synthesis with extracted data exists in parsed-therapy.xlsx -- PMID(s): 37140963. Target/mechanism, clinical application, indications, approval and precursor fields still need per-agent research and are intentionally left empty. Compound class inferred from precursor name (not stated outright) -- PMID 37140963: 'NOTA-PEG2Nle-CycMSHhex and NOTA-AocNle-CycMSHhex were synthesized using Fmoc chemistry'.