Tracer library / [99mTc]Tc(CO)3-NOTA-AocNle-CycMSHhex

[99mTc]Tc(CO)3-NOTA-AocNle-CycMSHhex

Also written as [Tc-99m]Tc(CO)3-NOTA-AocNle-CycMSHhex

Radionuclide: Tc-99m t½ 360.6 min
Modality: SPECT
Production route: —
Stage: Reported once
Syntheses indexed: 1

Melanoma Preclinical only, no clinical indication yet

What it is

Compound class: NOTA-conjugated lactam-cyclized α-MSH peptide (MC1R-targeting peptide)
Target / mechanism: MC1R (melanocortin 1 receptor)-specific binding on melanoma cells PMID 37140963
Clinical application: Melanoma imaging PMID 37140963
Theranostic pair: —

Published syntheses

Module	Cassette	Purification	Yield %	RCP %	Precursor / supplier	Source
Kit-based preparation Mallinckrodt	vendor cassette	HPLC	>90%	>95%	NOTA-AocNle-CycMSHhex	37140963 2023 Bioconjug Chem prepared using IsoLink kit - [99mTc]Tc(CO)3-NOTA-PEG2Nle-CycMSHhex and [99mTc]Tc(CO)3-NOTA-AocNle-CycMSHhex were readily prepared with more than 90% radiochemical yields

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Notes

Added at stage 22: promoted from 'Reported once' (single-article, no diagnostic pair at discovery) because a full-text synthesis with extracted data exists in parsed-therapy.xlsx -- PMID(s): 37140963. Target/mechanism, clinical application, indications, approval and precursor fields still need per-agent research and are intentionally left empty. Compound class inferred from precursor name (not stated outright) -- PMID 37140963: 'NOTA-PEG2Nle-CycMSHhex and NOTA-AocNle-CycMSHhex were synthesized using Fmoc chemistry'. | Stage 30 (2026-09-18): Modality was 'Therapy' -- a bucket value given to every agent found by the therapy-oriented bulk search (stages 21-22), not a source statement. Corrected to SPECT: Tc-99m is a gamma emitter used only for SPECT imaging. Linked articles: PMID 37140963.