Tracer library / [18F]ADPM06

Structure of ADPM06 (unlabelled parent compound, from PubChem) — Unlabelled parent compoundPubChem CID 71587749

[18F]ADPM06

Also written as [18F]ADPM06; [F-18]ADPM06

Radionuclide: F-18 t½ 109.77 min
Modality: PET
Production route: —
Stage: Preclinical
Syntheses indexed: 1

Preclinical only, no clinical indication yet

What it is

Compound class: BF2-chelated tetraaryl-azadipyrromethene photosensitizer
Target / mechanism: —
Clinical application: Photodynamic therapy planning and monitoring via biodistribution of photosensitizer, evaluated in tumor-bearing mice PMID 37458904
Theranostic pair: —

Published syntheses

Module	Cassette	Purification	Yield %	RCP %	Precursor / supplier	Source
COSMiC-Compact NMP Business Support	—	HPLC	13 ± 2.7% decay-corrected	> 95%	ADPM06 BOC Sciences	37458904 2023 EJNMMI Radiopharm Chem [18F]ADPM06 was synthesized using a COSMiC-Compact Synthesizer (NMP Business Support Company, Sanda, Japan). - The decay-corrected radiochemical yield from [18F]F− at the start of synthesis was 13 ± 2.7% (n = 5).

Precursor

Common precursor: —
Suppliers seen in the literature: —
Cited suppliers in indexed syntheses: BOC Sciences
Typical final purification: —

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Quality control Preliminary - inferred from compound class

Ph. Eur. monograph: not verified No Ph. Eur. check is recorded for this entry.
USP monograph: not verified No USP check is recorded for this entry.

AppearancepHRCP HPLCRCP TLCHPLC UVRadionuclidic (HPGe)Half-lifeActivityEndotoxins (LAL)SterilityFilter integrity

How this set was arrived at. base set per Ph. Eur. general monograph 0125 (rule); organic-phase radiosynthesis assumed from isotope/compound class, no synthesis data confirming it -> GC residual solvents (preliminary); conventional nucleophilic 18F-fluorination assumed from isotope/compound class, no synthesis data confirming K222 use -> Kryptofix test (preliminary)

Tests listed by reference only. Monograph texts are copyrighted and are not reproduced here. How these are derived

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Notes

Added from reverse module search (stage 6); 1 article(s) with F-18. Stage set/updated at stage 39 from PMID 37458904: 'In a positron emission tomography study using MDA-MB-231-HTB-26 tumor-bearing mice (female BALB/c-nu/nu), radioactivity accumulated in the bone at a relatively high level and in the tumor at a moderate level for 60 min after injection.'.