Tracer library / [18F]EKZ-001

[18F]EKZ-001

Also written as [18F]EKZ-001; [F-18]EKZ-001

Radionuclide: F-18 t½ 109.77 min
Modality: PET
Production route: —
Stage: Preclinical
Syntheses indexed: 1

CNS receptor and transporter imaging Preclinical only, no clinical indication yet

What it is

Compound class: HDAC6 inhibitor-based PET radioligand
Target / mechanism: HDAC6 (histone deacetylase 6) radioligand PMID 32159328
Clinical application: Neurodegenerative disorders, including Alzheimer's disease and amyotrophic lateral sclerosis PMID 32159328
Theranostic pair: —

Published syntheses

Module	Cassette	Purification	Yield %	RCP %	Precursor / supplier	Source
AllinOne (AiO) Trasis	vendor cassette	HPLC	14 ± 4 % decay-corrected	> 98 %	—	32159328 2020 ACS Chem Neurosci Trasis All-In-One (AIO) synthesizer - radiochemical yield of 14 ± 4 %

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Quality control Preliminary - inferred from compound class

Ph. Eur. monograph: not verified No Ph. Eur. check is recorded for this entry.
USP monograph: not verified No USP check is recorded for this entry.

AppearancepHRCP HPLCRCP TLCHPLC UVRadionuclidic (HPGe)Half-lifeActivityEndotoxins (LAL)SterilityFilter integrity

How this set was arrived at. base set per Ph. Eur. general monograph 0125 (rule); organic-phase radiosynthesis assumed from isotope/compound class, no synthesis data confirming it -> GC residual solvents (preliminary); conventional nucleophilic 18F-fluorination assumed from isotope/compound class, no synthesis data confirming K222 use -> Kryptofix test (preliminary)

Tests listed by reference only. Monograph texts are copyrighted and are not reproduced here. How these are derived

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Notes

Added from reverse module search (stage 6); 1 article(s) with F-18. Stage set/updated at stage 23 from PMID 32159328: 'This work supports the translation of [18F]EKZ-001 PET for first-in-human studies.'. | Stage 30 (2026-09-18): Stage was 'preclinical (supporting first-in-human translation)'; normalised to 'Preclinical', original wording kept here.