Tracers / [18F]EKZ-001

[18F]EKZ-001

Also written as [18F]EKZ-001; [F-18]EKZ-001
Radionuclide
F-18 t½ 109.77 min
Modality
PET
Production route
—
Stage
preclinical (supporting first-in-human translation)
Syntheses indexed
1
CNS receptor and transporter imagingPreclinical only, no clinical indication yet

What it is

Compound class
—
Target / mechanism
HDAC6 (histone deacetylase 6) radioligand PMID 32159328
Clinical application
Neurodegenerative disorders, including Alzheimer's disease and amyotrophic lateral sclerosis PMID 32159328
Theranostic pair
—

Regulatory status

FDA
—
EMA (centralised)
—
Other approvals
—
Brand names
—

Clinical use

Typical injected activity
—
Uptake time
—

Reported in the literature. Not a dosing recommendation.

Published syntheses

ModuleCassettePurificationYield %RCP %Precursor / supplierSource
AllinOne (AiO)
Trasis
vendor cassetteHPLC14 ± 4 %
yes
> 98 %—32159328
2020 ACS Chem Neurosci
Trasis All-In-One (AIO) synthesizer — radiochemical yield of 14 ± 4 %

Need this precursor?We can point you to suppliers for [18F]EKZ-001, or handle the enquiry for you.

Get in touch

Quality control Preliminary — inferred from compound class

Ph. Eur. monograph
—
USP monograph
—
AppearancepHRCP HPLCRCP TLCHPLC UVRadionuclidic (HPGe)Half-lifeActivityEndotoxins (LAL)SterilityFilter integrity
How this set was arrived at. base set per Ph. Eur. general monograph 0125 (rule); organic-phase radiosynthesis assumed from isotope/compound class, no synthesis data confirming it -> GC residual solvents (preliminary); conventional nucleophilic 18F-fluorination assumed from isotope/compound class, no synthesis data confirming K222 use -> Kryptofix test (preliminary)

Tests listed by reference only. Monograph texts are copyrighted and are not reproduced here. How these are derived

Setting up quality control?We can help you scope the equipment needed to release [18F]EKZ-001.

Get in touch

Notes

Added from reverse module search (stage 6); 1 article(s) with F-18. Stage set/updated at stage 23 from PMID 32159328: 'This work supports the translation of [18F]EKZ-001 PET for first-in-human studies.'.