Tracers / [177Lu]Lu-DOTA-r-a-ABA-iodoCPCR4

[177Lu]Lu-DOTA-r-a-ABA-iodoCPCR4

Also written as [177Lu]DOTA-r-a-ABA-iodoCPCR4; [Lu-177]DOTA-r-a-ABA-iodoCPCR4
Radionuclide
Lu-177 t½ 9585 min
Modality
Therapy
Production route
—
Stage
preclinical study
Syntheses indexed
2
LymphomaPreclinical only, no clinical indication yet

What it is

Compound class
DOTA-r-a-ABA-iodoCPCR4 (cyclic pentapeptide CXCR4-targeting ligand, DOTA-conjugated)
Target / mechanism
CXCR4-targeting ligand PMID 32724470
Clinical application
CXCR4-targeted radioligand therapy in cancer (evaluated preclinically in Daudi human B cell lymphoma xenografts) PMID 32724470
Theranostic pair
<a href="/tracers/ga68-dotaraabaiodocpcr4/">ga68-dotaraabaiodocpcr4</a>

Regulatory status

FDA
—
EMA (centralised)
—
Other approvals
—
Brand names
—

Clinical use

Typical injected activity
—
Uptake time
—

Reported in the literature. Not a dosing recommendation.

Published syntheses

ModuleCassettePurificationYield %RCP %Precursor / supplierSource
——————32724470
2020 Theranostics
Manual synthesis————DOTA-r-a-ABA-iodoCPCR432724470
2020 Theranostics
All peptides and their respective natGa-, natLu-, natY- and natBi- complexes were synthesized in analogy to previously published protocols

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Quality control Preliminary — inferred from compound class

Ph. Eur. monograph
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USP monograph
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AppearancepHRCP HPLCHPLC UVRadionuclidic (HPGe)Half-lifeActivityEndotoxins (LAL)SterilityFilter integrityOsmolalityMolar activityMetal impuritiesLu-177m
How this set was arrived at. base set per Ph. Eur. general monograph 0125 (rule); radiometal tracer -> metal impurities (rule); Lu-177 preparation -> Lu-177m content (rule); therapeutic radiopharmaceutical -> osmolality (rule); receptor ligand with a saturable target -> molar activity (rule)

Tests listed by reference only. Monograph texts are copyrighted and are not reproduced here. How these are derived

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Notes

Added from reverse module search (stage 6); 1 article(s) with Lu-177. Compound class inferred from precursor name (not stated outright) -- PMID 32724470: 'DOTA-r-a-ABA-iodoCPCR4 (entry 14)'. Stage set/updated at stage 23 from PMID 32724470: 'will be further evaluated in preclinical and clinical CXCR4-targeted dosimetry and RLT studies.'.