Tracers / [111In]DOTA-MSC3
[111In]DOTA-MSC3
- Radionuclide
- In-111 t½ 4031.6 min
- Modality
- Therapy
- Production route
- —
- Stage
- Reported once
- Syntheses indexed
- 1
What it is
- Compound class
- Monoclonal antibody (anti-CAIX), DOTA-conjugated
- Target / mechanism
- Carbonic anhydrase IX (CAIX), a marker of tumor hypoxia PMID 41799189
- Clinical application
- —
- Theranostic pair
- <a href="/tracers/ac225-dotamsc3/">ac225-dotamsc3</a>
Regulatory status
- FDA
- —
- EMA (centralised)
- —
- Other approvals
- —
- Brand names
- —
Clinical use
- Typical injected activity
- —
- Uptake time
- —
Reported in the literature. Not a dosing recommendation.
Published syntheses
| Module | Cassette | Purification | Yield % | RCP % | Precursor / supplier | Source |
|---|---|---|---|---|---|---|
| Manual synthesis | — | — | — | — | DOTA-MSC3 | 41799189 2026 Theranostics Details regarding antibody conjugation, radiolabeling and cell culture are described in the supplemental methods. |
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Get in touchNotes
Added at stage 22: promoted from 'Reported once' (single-article, no diagnostic pair at discovery) because a full-text synthesis with extracted data exists in parsed-therapy.xlsx -- PMID(s): 41799189. Target/mechanism, clinical application, indications, approval and precursor fields still need per-agent research and are intentionally left empty. Compound class inferred from precursor name (not stated outright) -- PMID 41799189: 'Monoclonal anti-CAIX antibody DOTA-MSC3 was labeled with indium-111 (111In) or actinium-225 (225Ac)'.