Tracers / [177Lu]Lu-PSMA-I&T
[177Lu]Lu-PSMA-I&T
Also written as [177Lu]Lu-PSMA-I&T
- Radionuclide
- Lu-177 t½ 9585 min
- Modality
- Therapy
- Production route
- —
- Stage
- Investigational / clinical (academic use)
- Syntheses indexed
- 39
What it is
- Compound class
- Radiolabelled PSMA-targeting urea-based peptidomimetic (I&T = imaging-and-therapy ligand)
- Target / mechanism
- Prostate-specific membrane antigen (PSMA) PMID 26089548
- Clinical application
- PSMA-targeted radioligand therapy in metastatic castration-resistant prostate cancer PMID 26089548
- Theranostic pair
- <a href="/tracers/ga68-psma-it/">ga68-psma-it</a>
Regulatory status
- FDA
- No FDA (Drugs@FDA/openFDA): no PSMA-I&T product found (distinct from the approved PSMA-617/vipivotide and PSMA-11/gozetotide products)
- EMA (centralised)
- No EMA medicines register export (2026-09-09): no 'PSMA-I&T' entry
- Other approvals
- —
- Brand names
- —
Clinical use
- Typical injected activity
- —
- Uptake time
- —
Reported in the literature. Not a dosing recommendation.
Published syntheses
| Module | Cassette | Purification | Yield % | RCP % | Precursor / supplier | Source |
|---|---|---|---|---|---|---|
| Modular-Lab EAZY Eckert & Ziegler | vendor cassette | none | 96.3 ± 2.1 (synthesis no. 2-4) | — | PSMA-I&T piCHEM, Raaba-Grambach, Austria | 37233924 2023 EJNMMI Radiopharm Chem ModularLab EAZY (Eckert & Ziegler Eurotope GmbH, Berlin, Germany) — we increased the balanced radiochemical yield from 78 to 96.3% ± 2.1% (synthesis no. 2–4) |
| — Elysia-Raytest | vendor cassette | none | 97.2 ± 2.4% no | 99.3 ± 0.6% | PSMA-I&T ligand ITM | 42154134 2026 EJNMMI Radiopharm Chem The [177Lu]Lu-PSMA I&T was produced using Elysia-Raytest's GAIA/LUNA synthesis modules. — a radiochemical yield of 97.2 ± 2.4% (without decay correction) was obtained |
| — | — | — | — | — | — | 42474389 2026 Clin Nucl Med |
| Manual synthesis | — | — | — | — | PSMA-I&T precursor Scintomics, Fürstenfeldbruck, Germany | 42274762 2026 Eur J Nucl Med Mol Imaging radiolabeling was performed in-house |
| — | vendor cassette | none | 97.2 ± 2.4% no | 99.3 ± 0.6% | PSMA I&T ITM | 42154134 2026 EJNMMI Radiopharm Chem The [177Lu]Lu-PSMA I&T was produced using Elysia-Raytest's GAIA/LUNA synthesis modules. — a radiochemical yield of 97.2 ± 2.4% (without decay correction) was obtained |
| — | — | — | — | — | — | 41927282 2026 J Nucl Med |
| — | — | — | — | — | Carrier-added [177Lu]Lutetium chloride Isotopia Molecular Imaging Ltd | 41680829 2026 J Exp Clin Cancer Res |
| Kit-based preparation | — | — | — | — | — | 41610875 2026 Nuklearmedizin In-house preparations (using GMP-grade kits and in-house radiolabelling) |
| — | — | none | >97% | 50%, 70%, 97% | PSMA-I&T | 41474511 2025 EJNMMI Radiopharm Chem |
| — | — | — | — | — | — | 41043997 2025 J Nucl Med |
| — | — | — | — | — | PSMA-I&T | 40998733 2025 J Nucl Med |
| iPHASE MultiSyn iPHASE Technologies | vendor cassette | — | 99% ± 3% no | 94.3 ± 0.9% (0h HPLC) | PSMA-I&T Huayi | 40696084 2025 EJNMMI Radiopharm Chem This process was automated using an iPHASE MultiSyn radiochemistry module with sterile kits affording sterile and apyrogenic 177Lu-labeled radiopharmaceuticals in non-decay corrected yields > 95%. — a yield of 99% ± 3%. |
| Manual synthesis | — | — | — | more than 95% | PSMA-I&T ABX | 40147849 2025 J Nucl Med Radiolabeling of the DOTA compounds was done at 85°C for 25 min, using ascorbic acid buffer and no-carrier-added [177Lu]LuCl3 |
| — | — | — | — | — | — | 39847077 2025 Eur J Nucl Med Mol Imaging |
| — | — | — | — | — | PSMA I&T piCHEM, Raaba-Grambach, Austria | 39225826 2024 Eur J Nucl Med Mol Imaging |
| — | — | — | — | — | — | 38960712 2024 J Nucl Med |
| — | — | — | — | — | PSMA I&T (DOTAGA) | 38855174 2024 Theranostics |
| — | — | — | — | — | — | 38724653 2024 Eur J Nucl Med Mol Imaging |
| — | — | — | — | — | DOTAGA-(I - y) fk-fk (Sub - KuE) | 38577331 2024 Front Oncol |
| Scintomics GRP / GRP-3V Scintomics | vendor cassette | — | >95% | >95% | PSMA-I&T | 38378689 2024 Breast Cancer Res a cassette synthesizer type GRP 3 V (Scintomics, Germany) was used — Radiochemical purities and yields were > 95% (measured with radio-HPLC). |
| — | — | — | — | — | — | 38069337 2023 Int J Mol Sci |
| Modular-Lab PharmTracer Eckert & Ziegler | vendor cassette | — | — | >95% | PSMAI&T Scintomics, Fürstenfeldbruck, Germany | 38067427 2023 Molecules Radiosyntheses were performed on a Modular-Lab PharmTracer (Eckert & Ziegler GmbH, Berlin, Germany) using the corresponding single-use disposable cassettes. |
| — | — | — | — | — | — | 37853247 2023 EJNMMI Phys |
| Modular-Lab EAZY Eckert & Ziegler | vendor cassette | none | 96.3 ± 2.1 | — | PSMA-I&T piCHEM, Raaba-Grambach, Austria | 37233924 2023 EJNMMI Radiopharm Chem All three radiopharmaceuticals were successfully synthesized in high radiochemical purities and yields on the ML Eazy. — we increased the balanced radiochemical yield from 78 to 96.3% ± 2.1% (synthesis no. 2–4) |
| Modular-Lab PharmTracer Eckert & Ziegler | vendor cassette | SPE | — | 96.9 ± 0.5% | PSMA I&T piCHEM, Raaba-Grambach, Austria | 36971890 2023 EJNMMI Radiopharm Chem [177Lu]Lu-PSMA I&T was prepared using an automated cassette based synthesis module (PharmTracer, Modular Lab, Eckert&Ziegler, Berlin, Germany) |
| — | — | — | — | — | — | 36629878 2023 Eur J Nucl Med Mol Imaging |
| Scintomics GRP / GRP-3V Scintomics | vendor cassette | none | — | — | PSMA-I&T ABX | 36166155 2022 EJNMMI Radiopharm Chem [177Lu]Lu-PSMA-I&T and [177Lu]Lu-PSMA-617 was produced with a Scintomics GRP module |
| Manual synthesis | — | — | 96.8 ± 0.9% | <95% in 24 h | PSMA-I&T ABX | 35807385 2022 Molecules For the radiolabeling of [177Lu]Lu-PSMA-I&T, a manual synthesis was used. — A typical synthesis time for the complexation reaction yielding [177Lu]Lu-PSMA I&T in 60 min with a radiochemical yield of 96.8 ± 0.9% (n = 5). |
| — | — | — | — | — | — | 35650263 2022 Eur J Nucl Med Mol Imaging |
| Manual synthesis | — | — | — | >95% | PSMA I&T precursor | 35086894 2022 J Nucl Med 177Lu labeling of PSMA ligands according to standard manual procedures resulted in a radiochemical purity of more than 95% |
| — | — | — | — | — | — | 34887335 2022 J Nucl Med |
| — | — | — | — | — | — | 33840558 2021 Eur Urol |
| — | — | — | — | — | PSMA-I&T | 33778927 2021 Curr Oncol Rep |
| Manual synthesis | — | — | >95% | >90% | PSMA-I&T Prof. Dr. Hans-Jürgen Wester, Technische Universität München | 33094433 2021 Eur J Nucl Med Mol Imaging Labeling of PSMA-617, PSMA-I&T, and JVZ-007 was performed as previously described — For all labelings, the radiochemical yield was > 95% and the radiochemical purity was > 90%. |
| — | — | — | — | — | PSMA-I&T | 32374450 2020 J Labelled Comp Radiopharm using the same synthesis module |
| — | — | — | 98% | — | PSMA-I&T | 40425733 2026 Nat Protoc |
| — | — | — | — | — | PSMA I&T | 26089548 2015 J Nucl Med |
| — | — | — | — | — | — | 42696922 2026 Appl Radiat Isot |
| — | — | — | — | — | — | 42324414 2026 Mol Imaging Biol |
Precursor
- Common precursor
- PSMA-I&T PMID 37233924 (DOI 10.1186/s41181-023-00196-1)
- Suppliers seen in the literature
- piCHEM (Raaba-Grambach, Austria)
- Cited suppliers in indexed syntheses
- ABX, Huayi, ITM, Isotopia Molecular Imaging Ltd, Prof. Dr. Hans-Jürgen Wester, Scintomics, Fürstenfeldbruck, piCHEM
- Typical final purification
- none (direct sterile filtration, no chromatographic step)
Need this precursor?We can point you to suppliers for [177Lu]Lu-PSMA-I&T, or handle the enquiry for you.
Get in touchQuality control Derived from the published synthesis
- Ph. Eur. monograph
- —
- USP monograph
- —
How this set was arrived at. base set per Ph. Eur. general monograph 0125 (rule); radiometal tracer -> metal impurities (rule); Lu-177 preparation -> Lu-177m content (rule); therapeutic radiopharmaceutical -> osmolality (rule); receptor ligand with a saturable target -> molar activity (rule)
Tests listed by reference only. Monograph texts are copyrighted and are not reproduced here. How these are derived
Setting up quality control?We can help you scope the equipment needed to release [177Lu]Lu-PSMA-I&T.
Get in touchNotes
Added from reverse module search (stage 6); 10 article(s) with Lu-177.