Tracers / [68Ga]Ga-PSMA-I&T
[68Ga]Ga-PSMA-I&T
Also written as [68Ga]Ga-PSMA-I&T
- Radionuclide
- Ga-68 t½ 67.71 min
- Modality
- PET
- Production route
- —
- Stage
- —
- Syntheses indexed
- 8
What it is
- Compound class
- PSMA-targeted urea-based small molecule ligand (EuK-Sub-kff-DOTAGA)
- Target / mechanism
- Prostate-specific membrane antigen (PSMA) PMID 33679149
- Clinical application
- PET/CT imaging of biochemically recurrent prostate cancer PMID 26975008
- Theranostic pair
- <a href="/tracers/lu177-psma-it/">lu177-psma-it</a>
Regulatory status
- FDA
- —
- EMA (centralised)
- —
- Other approvals
- —
- Brand names
- —
Clinical use
- Typical injected activity
- —
- Uptake time
- —
Reported in the literature. Not a dosing recommendation.
Published syntheses
| Module | Cassette | Purification | Yield % | RCP % | Precursor / supplier | Source |
|---|---|---|---|---|---|---|
| GAIA Elysia-Raytest | vendor cassette | SPE | 65% | >95% (HPLC) | PSMA-I&T ABX | 38424422 2024 Curr Radiopharm A GAIA® synthesis module and a GALLIAD® generator were used. — the results obtained with this buffer were considerably better, with a 65% RCY and a >95% RCP in HPLC. |
| — | — | — | — | — | EuK-Sub-kff-68Ga-DOTAGA | 26975008 2016 Clin Nucl Med |
| Scintomics GRP / GRP-3V Scintomics | vendor cassette | SPE | — | — | PSMA I&T | 40897948 2025 Mol Imaging Biol Similarly, [68 Ga]Ga-PSMA I&T was also synthesized using the Scintomics system for comparison scans. |
| — | — | — | — | — | — | 40304782 2025 Eur J Nucl Med Mol Imaging |
| — | — | — | — | — | PSMA I&T (DOTAGA) | 38855174 2024 Theranostics |
| Scintomics GRP / GRP-3V Scintomics | vendor cassette | SPE | — | >99% | PSMA I&T (EuK-Sub-kf-(3-iodo-y-) DOTAGA) ABX | 33679149 2021 Turk J Chem Original Scintomics radiosynthesis module equipped with cassette for the labelling of PSMA I&T peptide. |
| — | — | — | — | — | PSMA I&T | 26089548 2015 J Nucl Med |
| — | — | — | — | — | — | 32149792 2020 Clin Nucl Med |
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Get in touchQuality control Derived from the published synthesis
- Ph. Eur. monograph
- —
- USP monograph
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How this set was arrived at. base set per Ph. Eur. general monograph 0125 (rule); radiometal tracer -> metal impurities (rule); Ga-68, generator-produced per synthesis data (PMID 38424422) -> Ge-68 breakthrough; receptor ligand with a saturable target -> molar activity (rule)
Tests listed by reference only. Monograph texts are copyrighted and are not reproduced here. How these are derived
Setting up quality control?We can help you scope the equipment needed to release [68Ga]Ga-PSMA-I&T.
Get in touchNotes
Added from reverse module search (stage 6); 5 article(s) with Ga-68. Compound class inferred from precursor name (not stated outright) -- PMID 33679149: 'EuK-Sub-kf-(3-iodo-y-), DOTAGA'.