Tracers / [68Ga]Ga-Pentixafor
[68Ga]Ga-Pentixafor
Also written as [68Ga]Ga-PentixaFor; [68Ga]PentixaFor; [Ga-68]Ga-PentixaFor; [Ga-68]PentixaFor; Ga-68 PENTIXAFOR; Ga-68-Pentixafor; PENTIXAFOR
- Radionuclide
- Ga-68 t½ 67.71 min
- Modality
- PET
- Production route
- —
- Stage
- Investigational (academic clinical studies)
- Syntheses indexed
- 65
What it is
- Compound class
- Radiolabelled cyclic pentapeptide, CXCR4 antagonist analogue
- Target / mechanism
- Chemokine receptor CXCR4, overexpressed in several haematologic and solid malignancies PMID 35674738
- Clinical application
- CXCR4-receptor imaging in lymphoproliferative disorders (lymphoma, multiple myeloma) and other CXCR4-overexpressing tumours PMID 35674738
- Theranostic pair
- <a href="/tracers/lu177-pentixather/">lu177-pentixather</a>
Regulatory status
- FDA
- No FDA (Drugs@FDA/openFDA): no CXCR4/pentixafor product found (searched substance_name 'pentixafor')
- EMA (centralised)
- No EMA medicines register export (2026-09-09): no 'pentixafor' entry
- Other approvals
- —
- Brand names
- —
Clinical use
- Typical injected activity
- —
- Uptake time
- —
Reported in the literature. Not a dosing recommendation.
Published syntheses
| Module | Cassette | Purification | Yield % | RCP % | Precursor / supplier | Source |
|---|---|---|---|---|---|---|
| Scintomics GRP / GRP-3V Scintomics | — | — | — | — | — | 26909116 2016 Theranostics fully GMP compliant automated synthesizer (GRP, Scintomics, Germany) |
| EasyOne Trasis | vendor cassette | SPE | 91 ± 5% yes | >99.4% | Pentixafor MedChemExpress | 41701433 2026 EJNMMI Radiopharm Chem The fully automated synthesis of [68Ga]Ga-Pentixafor was also performed with Trasis EasyOne synthesizer. — The corrected yield of the labelled products was 91 ± 5% (72 ± 5% non-decay corrected). |
| Modular-Lab Standard Eckert & Ziegler | fixed tubing | SPE | 84.4±0.9% no | 99.4±0.3% | DOTA-Pentixafor Lympholucin, South Korea | 39050235 2024 Asia Ocean J Nucl Med Biol Automated radiosynthesis module (Modular-Lab Standard) was from Eckert & Ziegler, Germany. — The non-decay corrected (ndc) RCY for [68Ga]Ga-Pentixafor, [68Ga]Ga-FAPI-4 and [68Ga]Ga-DOTATATE were found to be (84.4±0.9)% (n=12) |
| Scintomics GRP / GRP-3V Scintomics | vendor cassette | — | — | — | — ABX | 33805264 2021 Diagnostics (Basel) a fully automated, GMP-compliant method using a GRP module (Scintomics, Fürstenfeldbruck, Germany) that was equipped with disposable single-use cassette kits (ABX, Radeberg, Germany) was used |
| — Scintomics; ABX | vendor cassette | — | — | — | CPCR4.2 ABX | 33579381 2021 Cancer Imaging Pentixafor was prepared in a fully automated procedure using a module equipped with a single-use cassette kit (Scintomics GmbH, Germany; ABX, Germany) [12]. |
| Scintomics GRP / GRP-3V Scintomics | — | SPE | — | — | Pentixafor | 33391493 2021 Theranostics [68Ga]Pentixafor was synthesized using a fully automated Scintomics GRP+ module. |
| — | — | SPE | — | >95% | pentixafor ABX | 33287237 2020 Biomolecules |
| Scintomics GRP / GRP-3V Scintomics | vendor cassette | — | — | — | — | 30191351 2018 EJNMMI Res Synthesis of 68Ga-Pentixafor was performed on a fully automated, GMP-compliant procedure using GRP module (Scintomics GmbH, Germany) equipped with disposable single-use cassette kits following the previously described method [19, 21]. |
| Scintomics GRP / GRP-3V Scintomics | vendor cassette | — | — | > 98% | Pentixafor Scintomics, Fürstenfeldbruck, Germany | 29228566 2017 Oncotarget using a GRP® module (SCINTOMICS GmbH, Fürstenfeldbruck, Germany) |
| Scintomics GRP / GRP-3V Scintomics | — | — | — | — | — | 28529632 2017 Theranostics fully GMP compliant automated synthesizer (GRP, Scintomics, Germany) |
| Scintomics GRP / GRP-3V Scintomics | vendor cassette | SPE | — | — | Pentixafor Scintomics, Fürstenfeldbruck, Germany | 28042328 2017 Theranostics a GRP® module (SCINTOMICS GmbH, Germany) |
| Scintomics GRP / GRP-3V Scintomics | vendor cassette | SPE | — | — | Pentixafor Scintomics, Fürstenfeldbruck, Germany | 26843617 2016 Oncotarget using a GRP® module (SCINTOMICS GmbH, Germany) equipped with a disposable single-use cassette kit (ABX, Germany) |
| Scintomics GRP / GRP-3V Scintomics | vendor cassette | — | — | — | Pentixafor | 25736399 2015 EMBO Mol Med using a GRP® module (SCINTOMICS GmbH, Germany) |
| Modular-Lab Standard Eckert & Ziegler | fixed tubing | SPE | 97.11 ± 0.60 yes | 99.4 ± 0.3 | Pentixafor acetate (DOTA conjugated Pentixafor) Lympholucin, South Korea | 39987209 2025 Sci Rep Modular-Lab Standard (a fixed tubing or non-cassette based fully automated radiochemistry module) — The decay corrected RCY of all the produced batches of [68Ga]Ga-Pentixafor (n = 16) were in the range of (97.11 ± 0.60)% |
| — Elysia-Raytest | vendor cassette | SPE | 87.0% yes | 99.1% (ITLC), 99.8% (HPLC) | PentixaFor PentixaPharm | 36749409 2023 EJNMMI Radiopharm Chem commercial labeling synthesis module Gaia/Luna (Elysia-Raytest, GmbH, Straubenhardt, Germany) — the mean radiochemical yield was 87.0% [standard deviation (SD) 6.67%] |
| Scintomics GallElut Scintomics | — | SPE | — | >99% | pentixafor | 25825601 2015 Theranostics [68Ga]pentixafor was prepared using 3.5 nmol of pentixafor in a Gallelut+ module (SCINTOMICS GmbH, Germany) |
| Scintomics GRP / GRP-3V Scintomics | vendor cassette | SPE | — | >99% | pentixafor | 25825601 2015 Theranostics performed in a fully automated, GMP-compliant procedure using a GRP® module (SCINTOMICS GmbH, Germany) |
| Scintomics GRP / GRP-3V Scintomics | vendor cassette | SPE | — | — | Pentixafor Scintomics, Fürstenfeldbruck, Germany | 28529638 2017 Theranostics using a GRP® module (SCINTOMICS GmbH, Fürstenfeldbruck, Germany) |
| Scintomics GRP / GRP-3V Scintomics | — | SPE | — | — | Pentixafor | 28932900 2018 Eur J Nucl Med Mol Imaging [68Ga]Pentixafor production was carried out as already described [22, 23] in a fully automated manner by using a Scintomics GRP module. |
| — | — | — | — | — | — | 31408441 2019 J Clin Invest |
| — | — | — | — | — | — | 34417915 2021 EJNMMI Res |
| Scintomics GRP / GRP-3V Scintomics | — | — | — | — | — | 35966583 2022 Theranostics fully GMP compliant automated synthesizer (GRP, Scintomics, Fürstenfeldbruck, Germany) |
| Modular-Lab PharmTracer Eckert & Ziegler | vendor cassette | SPE | 94.7 yes | 99.8% | PentixaFor PentixaPharm | 32107654 2020 EJNMMI Radiopharm Chem Modular Lab PharmTracer (MLPT) from Eckert & Ziegler — 50 μg PentixaFor resulted in 94.7% radiochemical yield (RCY, n.d.c.) in the product vial |
| Scintomics GRP / GRP-3V Scintomics | vendor cassette | SPE | 73.1% ± 7.7% yes | >99% | CPCR4.2 trifluoroacetate ABX | 34658546 2021 Indian J Nucl Med fully automatic synthesizer (Scintomics, Munich, Germany) — Mean radiolabelling efficiency of 73.1% ± 7.7% (n = 57) was obtained with synthesis time approximatively of 34 min |
| — | — | — | — | — | — | 40269029 2025 Sci Rep |
| Scintomics GRP / GRP-3V Scintomics | vendor cassette | — | — | — | — ABX | 29721166 2018 Oncotarget [68Ga]-Pentixafor was synthesized in a fully automated procedure on a Scintomics GRP module (SCINTOMICS GmbH, Germany) |
| — | — | — | — | — | — | 31004184 2019 Eur J Nucl Med Mol Imaging |
| — | — | — | — | — | — | 41706122 2026 Eur J Nucl Med Mol Imaging |
| — Scintomics | — | — | — | — | — | 29967943 2018 Eur J Nucl Med Mol Imaging connected to an automated module (Scintomics, Fürstenfeldbruck, Germany) |
| Scintomics GRP / GRP-3V Scintomics | vendor cassette | — | — | — | Pentixafor | 29290814 2018 Theranostics using a GRP® module (SCINTOMICS GmbH, Fürstenfeldbruck, Germany) |
| — | — | — | — | — | — | 31410585 2019 EJNMMI Res |
| Scintomics GRP / GRP-3V Scintomics | — | — | — | — | — | 31281504 2019 Theranostics [68Ga]Ga-Pentixafor production was carried out, as previously described, in a fully automated manner using a Scintomics GRP module |
| — | — | — | — | — | — | 32724470 2020 Theranostics |
| — | — | — | — | — | — | 42244984 2026 Theranostics |
| — | — | — | — | — | — | 41807884 2026 Mol Diagn Ther |
| Manual synthesis | — | SPE | 83 ± 5% yes | 98.6 ± 0.4% | Pentixafor Nanchang Tanzhen Biological Technology Co., Ltd., China | 41764676 2026 EJNMMI Radiopharm Chem Radiolabeling of 68Ga with DOTA-TATE, Pentixafor and FAP-2286 was performed manually using a similar operating procedure — 83 ± 5% |
| EasyOne Trasis | vendor cassette | SPE | 91.06 yes | >99.4% | Pentixafor precursor MedChemExpress | 41701433 2026 EJNMMI Radiopharm Chem The fully automated synthesis of [68Ga]Ga-Pentixafor was also performed with Trasis EasyOne synthesizer. — 91,06% |
| — | — | — | — | — | — | 40447542 2025 Semin Nucl Med |
| — | — | — | — | — | — | 40323995 2025 Clin Nucl Med |
| FASTlab 2 GE HealthCare | custom manifold | none | — | 98.64 ± 0.26 | DOTA-(Tyr3)-pentixafor ABX | 39598846 2024 Molecules Automated labeling of the precursor was accomplished using a FASTLab 2 synthesizer. |
| Modular-Lab Standard Eckert & Ziegler | fixed tubing | SPE | 84.4±0.9% no | 99.4±0.3% | DOTA-Pentixafor Lympholucin, South Korea | 39050235 2024 Asia Ocean J Nucl Med Biol Automated radiosynthesis module (Modular-Lab Standard) was from Eckert & Ziegler, Germany. — The non-decay corrected (ndc) RCY for [68Ga]Ga-Pentixafor, [68Ga]Ga-FAPI-4 and [68Ga]Ga-DOTATATE were found to be (84.4±0.9)% (n=12) |
| — | — | — | — | — | — | 38082196 2024 Eur J Nucl Med Mol Imaging |
| Manual synthesis | — | SPE | — | — | pentixafor PentixaPharm | 37989124 2024 Radiat Res Twenty micrograms of pentixafor (PentixaPharm®, Germany, reconstituted in metal-free H2O) was labeled with ~3–4 μCi (111–148 MBq) of 68Ga in 0.5 ml 0.4 M sodium acetate buffer (pH 5.3–5.5) at 95°C for 15 min. |
| — | — | — | — | — | — | 37286923 2023 Mol Imaging Biol |
| Scintomics GRP / GRP-3V Scintomics | vendor cassette | SPE | — | — | Pentixafor PentixaPharm | 35889351 2022 Molecules the automated synthesis module Scintomics GRPTM (Scintomics GmbH, Fürstenfeldbruck, Germany) |
| — | — | — | — | — | — | 33550492 2022 Eur J Nucl Med Mol Imaging |
| — | — | — | — | — | — | 32724470 2020 Theranostics |
| Modular-Lab PharmTracer Eckert & Ziegler | vendor cassette | SPE | 94.7 no | 99.8% | PentixaFor PentixaPharm | 32107654 2020 EJNMMI Radiopharm Chem Modular Lab PharmTracer (Eckert & Ziegler Eurotope GmbH, Germany) — 50 μg PentixaFor resulted in 94.7% radiochemical yield (RCY, n.d.c.) in the product vial |
| — Scintomics | — | SPE | — | — | pentixafor | 30042959 2016 Tomography [68Ga]pentixafor was prepared on a fully automated system (Scintomics GmbH) similar to that previously described (42) |
| Scintomics GRP / GRP-3V Scintomics | vendor cassette | — | — | — | Pentixafor | 29290814 2018 Theranostics using a GRP® module (SCINTOMICS GmbH, Fürstenfeldbruck, Germany) equipped with disposable single-use cassette kits |
| — | — | — | — | — | — | 26877786 2016 Theranostics |
| Scintomics GRP / GRP-3V Scintomics | vendor cassette | SPE | — | — | Pentixafor Scintomics, Fürstenfeldbruck, Germany | 26843617 2016 Oncotarget using a GRP® module (SCINTOMICS GmbH, Germany) equipped with a disposable single-use cassette kit (ABX, Germany) |
| — | — | HPLC | 57 | 98 ± 0.22% | PENTIXAFOR | 35190517 2022 Nucl Med Commun |
| — | — | — | — | — | — | 35452014 2022 Clin Nucl Med |
| — | — | — | — | — | — | 28729430 2018 J Nucl Med |
| — | — | — | — | — | — | 27819856 2017 Clin Nucl Med |
| — | — | — | — | — | — | 25698782 2015 J Nucl Med |
| — | — | — | 94.8 ± 2.6% | — | — | 37679888 2023 J Labelled Comp Radiopharm on the Trasis miniAllinOne synthesizer — Validation batches were performed with a radiochemical yield of 94.8 ± 2.6%. |
| — | — | — | — | — | — | 30002148 2018 Stroke |
| — | — | — | — | — | — | 29279316 2018 Hypertension |
| — | — | — | — | — | — | 28775206 2018 J Nucl Med |
| — | — | — | — | — | — | 42544987 2026 Clin Nucl Med |
| — | — | — | — | — | — | 42544986 2026 Clin Nucl Med |
| — | — | — | — | — | — | 42273741 2026 Circ Cardiovasc Imaging |
| — | — | — | — | — | — | 42018345 2026 Clin Exp Rheumatol |
Precursor
- Common precursor
- Pentixafor (peptide precursor) PMID 41701433 (DOI 10.1186/s41181-026-00426-2)
- Suppliers seen in the literature
- MedChemExpress (Monmouth Junction, NJ, USA)
- Cited suppliers in indexed syntheses
- ABX, Lympholucin, MedChemExpress, Nanchang Tanzhen Biological Technology Co., Ltd., PentixaPharm, Scintomics, Fürstenfeldbruck
- Typical final purification
- SPE
Need this precursor?We can point you to suppliers for [68Ga]Ga-Pentixafor, or handle the enquiry for you.
Get in touchQuality control Derived from the published synthesis
- Ph. Eur. monograph
- —
- USP monograph
- —
How this set was arrived at. base set per Ph. Eur. general monograph 0125 (rule); radiometal tracer -> metal impurities (rule); Ga-68, generator-produced per synthesis data (PMID 41701433) -> Ge-68 breakthrough; receptor ligand with a saturable target -> molar activity (rule)
Tests listed by reference only. Monograph texts are copyrighted and are not reproduced here. How these are derived
Setting up quality control?We can help you scope the equipment needed to release [68Ga]Ga-Pentixafor.
Get in touchNotes
Added from reverse module search (stage 6); 49 article(s) with Ga-68.