Tracer library / [177Lu]Lu-pentixather
[177Lu]Lu-pentixather
Also written as [177Lu]PentixaTher; [Lu-177]PentixaTher; Lu-177 Pentixather; Lu-177-Pentixather; PentixaTher
- Radionuclide
- Lu-177 t½ 9585 min
- Modality
- Therapy
- Production route
- —
- Stage
- Clinical research
- Syntheses indexed
- 3
What it is
- Compound class
- Radiolabelled cyclic pentapeptide, CXCR4 ligand (therapeutic beta-emitter conjugate)
- Target / mechanism
- Chemokine receptor CXCR4 PMID 26564323
- Clinical application
- CXCR4-directed endoradiotherapy in advanced-stage multiple myeloma with extensive intra- and extramedullary disease (first-in-human) PMID 26564323
- Theranostic pair
- [68Ga]Ga-Pentixafor
Regulatory status
- FDA
- No FDA (Drugs@FDA/openFDA): no pentixather product found
- EMA (centralised)
- No EMA medicines register export (2026-09-09): no 'pentixather' entry
- Other approvals
- —
- Brand names
- —
Published syntheses
| Module | Cassette | Purification | Yield % | RCP % | Precursor / supplier | Source |
|---|---|---|---|---|---|---|
| Scintomics GRP / GRP-3V Scintomics | — | none | — | >98% | pentixather | 28744319 2017 Theranostics [177Lu]pentixather was prepared using a Scintomics GRP synthesis module (Scintomics, Fürstenfeldbruck, Germany). |
| Manual synthesis | — | SPE | — | — | pentixather acetate ABX | 37989124 2024 Radiat Res Pentixather as a 1 μg/μl concentration in 300 μl of ascorbic acid buffer (50 mg/ml from Polatom, Poland) (pH 4) was mixed with 177LuCl3 (at approximately ratio of 1 μg per 37 MBq of 177Lutetium) at 95°C for 27 min with shaking (450 rpm). |
| Scintomics GRP / GRP-3V Scintomics | — | none | — | >98% | pentixather | 28744319 2017 Theranostics [177Lu]pentixather was prepared using a Scintomics GRP synthesis module (Scintomics, Fürstenfeldbruck, Germany) |
Clinical literature
Clinical studies in the indexed corpus, ordered by design (multicentre, prospective, retrospective, others, case reports last) and then by year. Titles and links only, as published; this is not a summary of the evidence.
- Side Effects of CXC-Chemokine Receptor 4-Directed Endoradiotherapy with Pentixather Before Hematopoietic Stem Cell Transplantation.2019 · J Nucl Med · Retrospective
- Myeloablative Radioligand Therapy Targeting C-X-C Motif Chemokine Receptor 4 in Advanced Multiple Myeloma.2025 · Clin Nucl Med · Clinical study
- CXCR4-directed endoradiotherapy with [177Lu]Pentixather added to total body irradiation for myeloablative conditioning in patients with relapsed/refractory acute myeloid leukemia.2025 · Theranostics · Clinical study
- CXCR4 expression in glioblastoma tissue and the potential for PET imaging and treatment with [68Ga]Ga-Pentixafor /[177Lu]Lu-Pentixather.2022 · Eur J Nucl Med Mol Imaging · Clinical study
- Dual Targeting of Acute Leukemia and Supporting Niche by CXCR4-Directed Theranostics.2018 · Theranostics · Clinical study
- First-in-Human Experience of CXCR4-Directed Endoradiotherapy with 177Lu- and 90Y-Labeled Pentixather in Advanced-Stage Multiple Myeloma with Extensive Intra- and Extramedullary Disease.2016 · J Nucl Med · Clinical study
Precursor
- Common precursor
- —
- Suppliers seen in the literature
- —
- Cited suppliers in indexed syntheses
- ABX
- Typical final purification
- —
Need this precursor?We can point you to suppliers for [177Lu]Lu-pentixather, or handle the enquiry for you.
Get in touchQuality control Preliminary - inferred from compound class
- Ph. Eur. monograph
- not verified No Ph. Eur. check is recorded for this entry.
- USP monograph
- not verified No USP check is recorded for this entry.
How this set was arrived at. base set per Ph. Eur. general monograph 0125 (rule); radiometal tracer -> metal impurities (rule); Lu-177 preparation -> Lu-177m content (rule); therapeutic radiopharmaceutical -> osmolality (rule); receptor ligand with a saturable target -> molar activity (rule)
Tests listed by reference only. Monograph texts are copyrighted and are not reproduced here. How these are derived
Setting up quality control?We can help you scope the equipment needed to release [177Lu]Lu-pentixather.
Get in touchNotes
Added from reverse module search (stage 6); 3 article(s) with Lu-177. | Stage 30 (2026-09-18): Stage was 'Investigational (first-in-human / early clinical)'; normalised to 'Clinical research', original wording kept here.