Tracer library / [177Lu]Lu-DOTA-Rituximab

[177Lu]Lu-DOTA-Rituximab

Also written as [Lu-177]Lu-DOTA-Rituximab; [Lu-177]Lu-DOTA-rituximab; Lu-177-DOTA-Rituximab; Lu-177-DOTA-rituximab

Radionuclide: Lu-177 t½ 9584.6 min
Modality: Therapy
Production route: —
Stage: —
Syntheses indexed: 1

Lymphoma Dosimetry and biodistribution studies

What it is

Compound class: Anti-CD20 monoclonal antibody (rituximab) conjugated with DOTA chelator (radioimmunoconjugate)
Target / mechanism: CD20 antigen on B-cells (via rituximab antibody) PMID 27980563
Clinical application: Radioimmunotherapy of Non-Hodgkin's lymphoma PMID 27980563
Theranostic pair: —

Published syntheses

Module	Cassette	Purification	Yield %	RCP %	Precursor / supplier	Source
Kit-based preparation	—	none	98.7% to 99.0%	>98%	DOTA-SCN (p-SCN-Bn-DOTA) Macrocyclics	30568680 2018 Iran J Pharm Res the freeze-dried kit containing 2.0 mg of DOTA-anti-CD20 was dissolved in 0.5 mL of water and mixed with 100-900 MBq of [177Lu]LuCl3 or 90YCl3 - the radiochemical yield ranging from 98.7% to 99.0% and from 98.8% to 99.1% at 1 h for 177Lu-DOTA-Rituximab and 90Y-DOTA-Rituximab respectively

Clinical literature

Clinical studies in the indexed corpus, ordered by design (multicentre, prospective, retrospective, others, case reports last) and then by year. Titles and links only, as published; this is not a summary of the evidence.

Tumor Lesion Uptake of [ 177 Lu]Lu-DOTA-Rituximab in Skeletal and Splenic Disease in Diffuse Large B-Cell Lymphoma.
2025 · Clin Nucl Med · Case report

Precursor

Common precursor: —
Suppliers seen in the literature: —
Cited suppliers in indexed syntheses: Macrocyclics
Typical final purification: —

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Notes

Added at stage 21 from therapy-discovered.xlsx (bulk PubMed search by isotope/therapy-type/known-agent, not individually researched yet) -- 4 articles found. Target/mechanism, clinical application, indications, approval and precursor fields still need per-agent research and are intentionally left empty. Compound class inferred from precursor name (not stated outright) -- PMID 30568680: 'p-SCN-Bn-DOTA(2-(4-isothiocyanatobenzyl)-1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid)'.