Tracer library / [177Lu]Lu-DOTA-M5A
[177Lu]Lu-DOTA-M5A
Also written as [177Lu]Lu-DOTA-M5A
- Radionuclide
- Lu-177
- Modality
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- Production route
- —
- Stage
- Preclinical
- Syntheses indexed
- 1
What it is
Published syntheses
| Module | Cassette | Purification | Yield % | RCP % | Precursor / supplier | Source |
|---|---|---|---|---|---|---|
| Manual synthesis | — | SPE | >97% | ≥99.9% | DOTA-M5A Macrocyclics | 35433442 2022 Front Oncol mixture of 177Lu (15 MBq, in 0.04 M HCl, ITG GmbH) and DOTA-M5A (50 µg) dissolved in sodium acetate (0.2 M, pH 5.5) or ammonium acetate (0.1 M, pH 5.5) was stirred on the thermoshaker (TS-100C Smart, Biosan, Lativa) at 42°C for 1 h (350 rpm) — Both 1 and 2 h of incubation for labeling of DOTA-M5A (50 µg) with 15 MBq of 177Lu at 42°C resulted in more than 97% of radiolabeling yield |
Clinical literature
Clinical studies in the indexed corpus, ordered by design (multicentre, prospective, retrospective, others, case reports last) and then by year. Titles and links only, as published; this is not a summary of the evidence.
- Phase I Study of Yttrium-90 Radiolabeled M5A Anti-Carcinoembryonic Antigen Humanized Antibody in Patients with Advanced Carcinoembryonic Antigen Producing Malignancies.2020 · Cancer Biother Radiopharm · Clinical study
Precursor
- Common precursor
- —
- Suppliers seen in the literature
- —
- Cited suppliers in indexed syntheses
- Macrocyclics
- Typical final purification
- —
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Get in touchNotes
Added at stage 39 (2026-09-27) from a reverse search of the PubMed corpus's own unattached articles (articles that named a real compound not yet in this reference): 2 article(s) found under this name, not yet individually researched. Target/mechanism, clinical application, indications, approval, modality, stage and production route are intentionally left empty. PMIDs: 31910346, 35433442. Stage set/updated at stage 39 from PMID 35433442: 'Further in vitro and in vivo studies are warranted to confirm the current study findings.'.