Tracers / [177Lu]Lu-CE-21
[177Lu]Lu-CE-21
Also written as [Lu-177]Lu-CE-21
- Radionuclide
- Lu-177 t½ 9584.6 min
- Modality
- Therapy
- Production route
- —
- Stage
- first-in-human
- Syntheses indexed
- 1
What it is
- Compound class
- Anti-CEA nanobody (single-domain antibody) conjugate
- Target / mechanism
- Targets carcinoembryonic antigen (CEA) PMID 41275230
- Clinical application
- CEA-targeted theranostic platform combining PET imaging with radionuclide therapy in oncology PMID 41275230
- Theranostic pair
- <a href="/tracers/ga68-ce21/">ga68-ce21</a>
Regulatory status
- FDA
- —
- EMA (centralised)
- —
- Other approvals
- —
- Brand names
- —
Clinical use
- Typical injected activity
- —
- Uptake time
- —
Reported in the literature. Not a dosing recommendation.
Published syntheses
| Module | Cassette | Purification | Yield % | RCP % | Precursor / supplier | Source |
|---|---|---|---|---|---|---|
| Manual synthesis | — | none | 42.7 ± 2.8% | >95% | CEA-Nanobody (CE-21-NOTA conjugate) | 41275230 2025 J Nanobiotechnology Radiolabeling of [¹⁷⁷Lu]Lu-CE-Nanobody: A 1 mL solution of 0.05 M HCl was mixed with 0.3 mL of 0.25 M sodium acetate buffer, to which 20–50 µL of ¹⁷⁷Lu solution was added and the pH adjusted to 5. — The radiochemical yield was 42.7 ± 2.8%, with a radiochemical purity exceeding 95% as determined by radio-TLC (Fig. S3). |
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Get in touchNotes
Added at stage 22: promoted from 'Reported once' (single-article, no diagnostic pair at discovery) because a full-text synthesis with extracted data exists in parsed-therapy.xlsx -- PMID(s): 41275230. Target/mechanism, clinical application, indications, approval and precursor fields still need per-agent research and are intentionally left empty. Compound class inferred from precursor name (not stated outright) -- PMID 41275230: 'CEA-Nanobody (CE-21-NOTA conjugate)'. Stage set/updated at stage 23 from PMID 41275230: 'A high-affinity CEA-targeted nanobody for 68Ga PET imaging and 177Lu-based radioisotope therapy: preclinical and first-in-human evaluation.'.