Tracer library / [68Ga]CE-21

[68Ga]CE-21

Also written as [Ga-68]Ga-CE-21
Radionuclide
Ga-68 t½ 67.71 min
Modality
PET
Production route
—
Stage
Clinical research
Syntheses indexed
0

What it is

Compound class
CEA-targeted nanobody conjugated with NOTA chelator (CE-21-NOTA)
Target / mechanism
Carcinoembryonic antigen (CEA) PMID 41275230
Clinical application
PET/CT imaging of CEA-expressing tumors PMID 41275230
Theranostic pair
[177Lu]Lu-CE-21

Published syntheses

No synthesis has been parsed for this agent yet.

Clinical literature

Clinical studies in the indexed corpus, ordered by design (multicentre, prospective, retrospective, others, case reports last) and then by year. Titles and links only, as published; this is not a summary of the evidence.

  1. A high-affinity CEA-targeted nanobody for 68Ga PET imaging and 177Lu-based radioisotope therapy: preclinical and first-in-human evaluation.
    2025 · J Nanobiotechnology · Clinical study

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Notes

Added at stage 22: promoted from 'Reported once' (single-article, no diagnostic pair at discovery) because a full-text synthesis with extracted data exists in parsed-therapy.xlsx -- PMID(s): 41275230. Target/mechanism, clinical application, indications, approval and precursor fields still need per-agent research and are intentionally left empty. Compound class inferred from precursor name (not stated outright) -- PMID 41275230: 'CEA-Nanobody (CE-21-NOTA conjugate)'. Stage set/updated at stage 23 from PMID 41275230: 'A high-affinity CEA-targeted nanobody for 68Ga PET imaging and 177Lu-based radioisotope therapy: preclinical and first-in-human evaluation.'. | Stage 30 (2026-09-18): Stage was 'first-in-human'; normalised to 'Clinical research', original wording kept here. | Stage 30 (2026-09-18): Modality was 'Therapy' -- a bucket value given to every agent found by the therapy-oriented bulk search (stages 21-22), not a source statement. Corrected to PET: Ga-68 is a positron emitter used only for PET imaging. Linked articles: PMID 41275230.
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