Tracers / [111In]In-RM2

[111In]In-RM2

Also written as [111In]In-RM2
Radionuclide
In-111 t½ 4032 min
Modality
SPECT
Production route
Cyclotron solid target
Stage
Research
Syntheses indexed
2
Prostate cancerReceptor expression phenotypingDosimetry and biodistribution studies

What it is

Compound class
Peptide (bombesin antagonist)
Target / mechanism
Gastrin-releasing peptide receptor (GRPR) PMID 40736585 / DOI 10.1007/s00411-025-01137-z
Clinical application
SPECT imaging of gastrin-releasing peptide receptor (GRPR)-positive tumours, particularly prostate cancer (cited studies used the [113mIn]In-RM2 analogue) PMID 40736585 / DOI 10.1007/s00411-025-01137-z; PMID 39760843 / DOI 10.1007/s13246-024-01510-0
Theranostic pair
<a href="/tracers/ga68-rm2/">ga68-rm2</a>

Regulatory status

FDA
No Drugs@FDA / openFDA drug registry — no approved application found; search: https://www.accessdata.fda.gov/scripts/cder/daf/index.cfm?event=BasicSearch.process&searchTerm=In-111+RM2
EMA (centralised)
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Other approvals
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Brand names
—

Clinical use

Typical injected activity
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Uptake time
—

Reported in the literature. Not a dosing recommendation.

Published syntheses

ModuleCassettePurificationYield %RCP %Precursor / supplierSource
Manual synthesis———>95%RM240732291
2025 Pharmaceuticals (Basel)
Preparation of [111In]In-RM2. 5–10 µL of NaOAc (in H2O, 0.3 M) were added to 50 µL of [111In]InCl3
Manual synthesis————RM237584725
2023 Eur J Nucl Med Mol Imaging
For autoradiography studies, the peptides were labeled with indium-111 (Covidien, The Netherlands) [22].

Precursor

Common precursor
DOTA-conjugated GRPR-antagonist peptide RM2 PMID 39760843 / DOI 10.1007/s13246-024-01510-0
Suppliers seen in the literature
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Typical final purification
SPE

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Quality control Preliminary — inferred from compound class

Ph. Eur. monograph
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USP monograph
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AppearancepHRCP HPLCHPLC UVRadionuclidic (HPGe)Half-lifeActivityEndotoxins (LAL)SterilityFilter integrityMolar activityMetal impurities
How this set was arrived at. base set per Ph. Eur. general monograph 0125 (rule); radiometal tracer -> metal impurities (rule); receptor ligand with a saturable target -> molar activity (rule)

Tests listed by reference only. Monograph texts are copyrighted and are not reproduced here. How these are derived

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