Tracer library / [111In]In-RM2
[111In]In-RM2
Also written as [111In]In-RM2
- Radionuclide
- In-111 t½ 4032 min
- Modality
- SPECT
- Production route
- Cyclotron solid target
- Stage
- Research
- Syntheses indexed
- 2
What it is
- Compound class
- Peptide (bombesin antagonist)
- Target / mechanism
- Gastrin-releasing peptide receptor (GRPR) PMID 40736585 / DOI 10.1007/s00411-025-01137-z
- Clinical application
- SPECT imaging of gastrin-releasing peptide receptor (GRPR)-positive tumours, particularly prostate cancer (cited studies used the [113mIn]In-RM2 analogue) PMID 40736585 / DOI 10.1007/s00411-025-01137-z; PMID 39760843 / DOI 10.1007/s13246-024-01510-0
- Theranostic pair
- [68Ga]Ga-RM2
Regulatory status
- FDA
- No Drugs@FDA / openFDA drug registry — no approved application found; search: https://www.accessdata.fda.gov/scripts/cder/daf/index.cfm?event=BasicSearch.process&searchTerm=In-111+RM2
- EMA (centralised)
- —
- Other approvals
- —
- Brand names
- —
Published syntheses
| Module | Cassette | Purification | Yield % | RCP % | Precursor / supplier | Source |
|---|---|---|---|---|---|---|
| Manual synthesis | — | — | — | >95% | RM2 | 40732291 2025 Pharmaceuticals (Basel) Preparation of [111In]In-RM2. 5–10 µL of NaOAc (in H2O, 0.3 M) were added to 50 µL of [111In]InCl3 |
| Manual synthesis | — | — | — | — | RM2 | 37584725 2023 Eur J Nucl Med Mol Imaging For autoradiography studies, the peptides were labeled with indium-111 (Covidien, The Netherlands) [22]. |
Precursor
- Common precursor
- DOTA-conjugated GRPR-antagonist peptide RM2 PMID 39760843 / DOI 10.1007/s13246-024-01510-0
- Suppliers seen in the literature
- —
- Typical final purification
- SPE
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Get in touchQuality control Preliminary - inferred from compound class
- Ph. Eur. monograph
- not verified No Ph. Eur. check is recorded for this entry.
- USP monograph
- not verified No USP check is recorded for this entry.
How this set was arrived at. base set per Ph. Eur. general monograph 0125 (rule); radiometal tracer -> metal impurities (rule); receptor ligand with a saturable target -> molar activity (rule)
Tests listed by reference only. Monograph texts are copyrighted and are not reproduced here. How these are derived
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