Structure of FAPI-74 (unlabelled parent compound, from PubChem) — Unlabelled parent compoundPubChem CID 139400631

[68Ga]Ga-FAPI-74

Also written as FAPI-74; Ga-68 FAPI-74

Radionuclide: Ga-68 t½ 67.71 min
Modality: PET
Production route: —
Stage: —
Syntheses indexed: 1

Gastrointestinal and colorectal cancer Gynaecological cancer Hepatobiliary and pancreatic cancer Lung cancer Prostate cancer Thyroid cancer FAP-directed radioligand therapy Sarcoma (soft tissue and bone)

What it is

Compound class: FAP inhibitor (FAPI) PET tracer
Target / mechanism: Fibroblast activation protein (FAP) PMID 41779297
Clinical application: Various malignancies including pancreatic, sarcoma, colorectal and gastric cancer PMID 41787024
Theranostic pair: —

Published syntheses

Module	Cassette	Purification	Yield %	RCP %	Precursor / supplier	Source
—	—	SPE	—	> 98%	FAPI-74	41762411 2026 EJNMMI Radiopharm Chem

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Quality control Preliminary - inferred from compound class

Ph. Eur. monograph: not verified No Ph. Eur. check is recorded for this entry.
USP monograph: not verified No USP check is recorded for this entry.

AppearancepHRCP HPLCHPLC UVRadionuclidic (HPGe)Half-lifeActivityEndotoxins (LAL)SterilityFilter integrityMolar activityMetal impuritiesGe-68 breakthrough

How this set was arrived at. base set per Ph. Eur. general monograph 0125 (rule); radiometal tracer -> metal impurities (rule); Ga-68, generator production assumed (no synthesis data found) -> Ge-68 breakthrough (preliminary); receptor ligand with a saturable target -> molar activity (rule)

Tests listed by reference only. Monograph texts are copyrighted and are not reproduced here. How these are derived

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Notes

Added from reverse module search (stage 6); 8 article(s) with Ga-68. | Stage 28: added indication(s) onc-sarcoma from consolidated missing-rubric review.