Structure of PBR111 (unlabelled parent compound, from PubChem) — Unlabelled parent compoundPubChem CID 24895171

[18F]PBR111

Also written as [18F]PBR111; [F-18]PBR111

Radionuclide: F-18 t½ 109.77 min
Modality: PET
Production route: —
Stage: —
Syntheses indexed: 3

Inflammatory disease Alzheimer's disease Epilepsy Neuroinflammation Glioma and brain tumours Dosimetry and biodistribution studies

What it is

Compound class: second-generation TSPO PET radioligand
Target / mechanism: 18 kDa translocator protein (TSPO) PMID 40179687
Clinical application: Neuroinflammatory conditions such as Alzheimer's disease or multiple sclerosis; healthy volunteers studied for dosimetry PMID 40179687
Theranostic pair: —

Published syntheses

Module	Cassette	Purification	Yield %	RCP %	Precursor / supplier	Source
TRACERlab FX FN GE HealthCare	—	—	30±2% not corrected	>99%	p-toluenesulfonyl precursors	21852142 2012 Appl Radiat Isot radiosynthesis of [(18)F]PBR111 and [(18)F]PBR102 in the Tracerlab FX(FN) - 30±2% radiochemical yield non-decay-corrected for both tracers
TRACERlab MX GE HealthCare	—	—	25±2% not corrected	>99%	p-toluenesulfonyl precursors	21852142 2012 Appl Radiat Isot Tracerlab MX(FDG) (25±2% radiochemical yield non-decay-corrected for both tracers) - Tracerlab MX(FDG) (25±2% radiochemical yield non-decay-corrected for both tracers)
TRACERlab FX FN GE HealthCare	—	—	—	—	—	22104496 2012 Appl Radiat Isot using a TRACERlab FX-FN synthesizer

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Quality control Preliminary - inferred from compound class

Ph. Eur. monograph: not verified No Ph. Eur. check is recorded for this entry.
USP monograph: not verified No USP check is recorded for this entry.

AppearancepHRCP HPLCRCP TLCHPLC UVRadionuclidic (HPGe)Half-lifeActivityEndotoxins (LAL)SterilityFilter integrity

How this set was arrived at. base set per Ph. Eur. general monograph 0125 (rule); organic-phase radiosynthesis assumed from isotope/compound class, no synthesis data confirming it -> GC residual solvents (preliminary); conventional nucleophilic 18F-fluorination assumed from isotope/compound class, no synthesis data confirming K222 use -> Kryptofix test (preliminary)

Tests listed by reference only. Monograph texts are copyrighted and are not reproduced here. How these are derived

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Notes

Added from reverse module search (stage 6); 3 article(s) with F-18.