Tracer library / [18F]AlF-FAPI-74
[18F]AlF-FAPI-74
Also written as [18F]AlF-FAPI-74; [F-18]AlF-FAPI-74
- Radionuclide
- F-18 t½ 109.77 min
- Modality
- PET
- Production route
- —
- Stage
- —
- Syntheses indexed
- 8
What it is
- Compound class
- NOTA-conjugated FAP-inhibitor (quinoline-based small molecule) labeled via Al18F
- Target / mechanism
- Targets fibroblast activation protein (FAP) expressed on cancer-associated fibroblasts in tumor stroma PMID 34420105
- Clinical application
- PET imaging of cancer-associated fibroblasts via FAP targeting, used for tumor staging and monitoring stromal/CAF response to therapy PMID 41798720
- Theranostic pair
- —
Published syntheses
| Module | Cassette | Purification | Yield % | RCP % | Precursor / supplier | Source |
|---|---|---|---|---|---|---|
| AllinOne (AiO) Trasis | vendor cassette | SPE | 50.0 ± 10.3% decay-corrected | 97.1 ± 0.2% | NOTA-FAPI-74 ABX | 41391071 2025 EJNMMI Radiopharm Chem Trasis AllInOne® platform - corresponding to a decay-corrected radiochemical yield of 50.0 ± 10.3%, calculated relative to the starting activity in the target |
| In-house / custom built | — | — | 75 ± 5% | >99% | FAPI-74 | 41798720 2026 Chem Eng J the first fully-automated, droplet-based production of [18F]AlF-labeled compounds using a compact and cost-effective platform - high radiochemical yield (RCY, 75 ± 5%) |
| CFN-MPS200 Sumitomo | vendor cassette | SPE | 37.0 ± 4.3 | ≥ 97% | FAPI-74 precursor SOFIE | 34420105 2021 EJNMMI Radiopharm Chem cassette-type multi purpose synthesizer CFN-MPS200 - radiochemical yield was 37 ± 4% (n = 10) |
| In-house / custom built | — | — | 75 ± 5% | >99% | FAPI-74 | 41798720 2026 Chem Eng J report the first fully-automated, droplet-based production of [18F]AlF-labeled compounds using a compact and cost-effective platform - obtained with high radiochemical yield (RCY, 75 ± 5%) |
| — | — | HPLC | 15% | >99% | FAPI-74 | 41761350 2026 Cancer Imaging |
| AllinOne (AiO) Trasis | vendor cassette | SPE | 50.0 ± 10.3% decay-corrected | 97.1 ± 0.2% | NOTA-FAPI-74 ABX | 41391071 2025 EJNMMI Radiopharm Chem using the Trasis AllInOne® platform - corresponding to a decay-corrected radiochemical yield of 50.0 ± 10.3%, calculated relative to the starting activity in the target. |
| TRACERlab FX2 N GE HealthCare | — | — | 18.5 ± 2.5% | >95% | — | 34050679 2021 J Labelled Comp Radiopharm first developed on the flexible GE TRACERLab FX2N (FXN) platform - radiochemical yield (RCY) of 18.5 ± 2.5% (n = 5, relative to starting [18 F]fluoride) |
| AllinOne (AiO) Trasis | — | — | 20 ± 2.5% | >95% | — | 34050679 2021 J Labelled Comp Radiopharm later translated to the cassette-based module Trasis AllInOne (AIO) - production of [18 F]FAPI-74 in an isolated RCY of 20 ± 2.5% [n = 3] |
Clinical literature
Clinical studies in the indexed corpus, ordered by design (multicentre, prospective, retrospective, others, case reports last) and then by year. Titles and links only, as published; this is not a summary of the evidence.
- [18F]F-FAPI PET/CT and LAparoscopy in STagIng advanced gastric Cancer: a multicenter prospective study (PLASTIC-3 study).2025 · BMC Cancer · Prospective, multicentre
- Intra-patient comparison of tracer uptake and biodistribution of [68Ga]Ga-FAPI-46 and [18F]AlF-FAPI-74.2026 · Ann Nucl Med · Prospective
Precursor
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Get in touchQuality control Preliminary - inferred from compound class
- Ph. Eur. monograph
- not verified No Ph. Eur. check is recorded for this entry.
- USP monograph
- not verified No USP check is recorded for this entry.
How this set was arrived at. base set per Ph. Eur. general monograph 0125 (rule); receptor ligand with a saturable target -> molar activity (rule); organic-phase radiosynthesis assumed from isotope/compound class, no synthesis data confirming it -> GC residual solvents (preliminary)
Tests listed by reference only. Monograph texts are copyrighted and are not reproduced here. How these are derived
Setting up quality control?We can help you scope the equipment needed to release [18F]AlF-FAPI-74.
Get in touchNotes
Added from reverse module search (stage 6); 3 article(s) with F-18. Compound class inferred from precursor name (not stated outright) -- PMID 41391071: 'NOTA-FAPI-74'.